5' AAGCTTCCAC TACCTTGCCA CCCGCAATAA GAACGATTAC TTCTCCCTCG CCTT 54 Kec Pro tie Thr Asn 141 CTACCA CCTAAAGATC TCCCTCTTAT TTTTAGOTTG AACTCGTATA AACCAAAATT AATTACACCA GATAAA ATG CCA ATT ACA AAT -35 -10 BBS fut Lys ThT Hec Leu Il« Thr Tyr Ala Aap Ser Leu Gly Lye Asa Leu Lys Glu Leu Asn Glu A«n H e Glu Agn Tyr AAA ACA ATG TTC ATT ACT TAC GCA CAC ACT TTC OGT AAA AAT TTG AAA CAA TTG AAT GAA AAT ATT GAG...

AIMS To determine the frequency of alpha-1 antitrypsin (AAT) deficiency in children with chronic liver disease (CLD) and neonatal cholestasis syndrome (NCS). METHODS All children with NCS (n=23) or CLD (n=35) attending the Pediatric Gastroenterology Clinic between November 2003 and July 2005 were screened for AAT deficiency using phenotyping through isoelectric focusing of plasma. RESULTS O...

Alpha1-antitrypsin (AAT) deficiency was first described in 1963 together with its associations with severe early-onset basal panacinar emphysema. The genetic defects leading to deficiency have been elucidated and the pathophysiologic processes, clinical variation in phenotype, and the role of genetic modifiers have been recognized. Strategies to increase plasma (and hence tissue) concentrations...

Animal-assisted therapy and animal-assisted activities involve a nonhuman animal as a key therapeutic agent in some kind of intervention that may range from highly specified, as in AAT, to more casual, as in AAA. In this review I address the question: How important is the animal in animal therapy? In other words, does the recent literature strongly support the notion that a live animal, as oppo...

A 43-year-old black man had an 18-year history of apical lung cystic-bullous disease. Following two episodes of spontaneous pneumothorax and two instances of thoracotomy for bullectomy and pleural abrasion, he was found to have an intermediate AAT deficiency with an MZ phenotype. It is believed that this is the first case of localized bullous lung disease to be reported in association with any ...

A proper or singular abelian mapping from C to C n is parametrized by n meromorphic functions with at most 2n periods. We develop the existence and structure theorems of the classical theory of an abelian mapping purely on the basis of its defining functional equation, the so-called algebraic addition theorem (AAT), with no appeal to any representation as quotients of theta functions. We offer ...

Several lines of evidence, albeit most of them circumstant ia l, support the protease-antiprotease imbalance concept in the pathogenesis of emphysema. Neutrophil elastase (NE) has become the key enzyme for several reasons. NE is insufficiently inhibited by a( antitrypsin (AAT) (a 1 -proteinase inhibitor) in inherited deficiency states when the extracellular level of the predominant antiprotease...

Animal-Assisted Therapy (AAT) or Pet Therapy is a supportive goal-oriented intervention which is mainly result from human and animal interaction. [1][6] In this treatment process, a health professional/patients’ doctor have to determine which animal model should be accompanied with a specific clinical goal. This interventions can be followed by physical therapists, neurol‐ ogist, psychiatrist, ...

Forty-two cases of hepatocellular carcinoma (HCC) were examined for the presence of the inclusions of alpha-1-antitrypsin (AAT), which indicate a carrier state for the Pi Z gene. These were found in the non-neoplastic liver tissue of two cases of HCC and in one of the 98 control livers, a difference that is not statistically significant. Typical globules of AAT deficiency were not found in HCC ...