Bordetella pertussis Lipid A Glucosamine Modification Confers Resistance to Cationic 1 Antimicrobial Peptides and Increases Resistance to Outer Membrane Perturbation 2 3 4 5 Nita R. Shah, Robert E. W. Hancock, Rachel C. Fernandez# 6 7 Department of Microbiology and Immunology, The University of British Columbia, Vancouver, 8 Canada, V6T 1Z3 9 10 Running Title: Modified B. pertussis Lipid A Conf...

The efflux pump SmeDEF contributes to trimethoprim/sulfamethoxazole 1 resistance in Stenotrophomonas maltophilia 2 3 María Blanca Sánchez and José Luis Martínez* 4 Departamento de Biotecnología Microbiana, Centro Nacional de Biotecnología, CSIC, 5 Darwin 3, Cantoblanco, 28049 Madrid, Spain. 6 7 Corresponding author’s mailing address: 8 JLM e-mail: [email protected] 9 10 11 12 13 14 15 16 17 1...

in antimalarial dose optimization 2 3 NJ White 4 5 Mahidol-Oxford Tropical Medicine Research Unit, 6 Faculty of Tropical Medicine, Mahidol University, 7 Bangkok, Thailand. 8 9 Centre for Tropical Medicine, Churchill Hospital, 10 Oxford University, Oxford, United Kingdom 11 12 13 14 15 16 17 Correspondence: 18 Prof NJ White 19 Mahidol-Oxford Research Unit, 20 Faculty of Tropical Medicine, 21 Mah...

5 6 Running title: Linezolid-resistant clinical M. tuberculosis-isolates 7 8 9 Elvira Richter, Sabine Rüsch-Gerdes, Doris Hillemann* 10 11 Forschungszentrum Borstel, National Reference Center for Mycobacteria, D-23845 Borstel 12 13 14 15 * Correspondent author: 16 Mailing address: Forschungszentrum Borstel, National Reference Center for Mycobacteria, 17 Parkallee 18, D-23845 Borstel, Germany 18...

4 5 Liya Wang*, Ren Sun and Staffan Eriksson 6 Department of Anatomy, Physiology and Biochemistry, Section of Veterinary Medical 7 Biochemistry, SLU, The Biomedical Centre, P.O. Box 575, SE-751 23 Uppsala, Sweden 8 9 10 * Corresponding author: Tel: 46 18 471 4119; 11 Fax: 46 18 550762 12 e-mail: [email protected] 13 14 15 Running title: Thymidine kinase 2 and antiviral thymidine analogs. 16 Copy...

Weisi Wang, Zhiqiang Qin, Dan Zhu, Yufen Wei, Shizhu Li, Liping Duan b, # 5 National Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention, WHO 6 Collaborating Centre for Malaria, Schistosomiasis, and Filariasis, Key laboratory of Parasitology and Vector 7 Biology of the Chinese Ministry of Health, Shanghai, China. 8 Shanghai Key Laboratory of New Drug Design, Schoo...

A genome-wide screen for modulators of evolvability under toxic 1 antibiotic exposure 2 3 Orsolya Méhi, Balázs Bogos, Bálint Csörgő & Csaba Pál 4 5 Synthetic and Systems Biology Unit, Institute of Biochemistry. Biological Research 6 Center, Szeged. Hungary 7 8 $ Correspondence should be sent to C.P. ([email protected]) or 9 B.B. ([email protected]) 10 11 12 Short-form paper 13 Running head: Mod...

We described a comprehensive analysis of the molecular epidemiology of multidrug-resistant (MDR) P. aeruginosa. Molecular analysis included typing by Pulsed Field Gel Electrophoresis, identification of genes of interest through PCR-based assays and sequencing of target genes. Case-control study was conducted to better understand the prognostic of patients and the impact of inappropriate therapy...

Enterococci are nosocomial pathogen with multiple-drug resistance by intrinsic and extrinsic mechanisms. Aminoglycosides along with cell wall inhibitors are given clinically for treating enterococcal infections. 178 enterococcal isolates were analyzed in this study. E. faecalis is identified to be the predominant Enterococcus species, along with E. faecium, E. avium, E. hirae, E. durans, E. dis...