نتایج جستجو برای: a549 cells

تعداد نتایج: 1384602  

2016
Hsin-Ru Lin Yi-Hsuan Wu Wei-Chen Yen Chuen-Mao Yang Daniel Tsun-Yee Chiu

Glucose-6-phosphate dehydrogenase (G6PD) provides the reducing agent NADPH to meet the cellular needs for reductive biosynthesis and the maintenance of redox homeostasis. G6PD-deficient cells experience a high level of oxidative stress and an increased susceptibility to viral infections. Cyclooxygenase-2 (COX-2) is a key mediator in the regulation of viral replication and inflammatory response....

2014
WEIHAN YANG YU WANG QIANG PU SUJUAN YE QINGPING MA JIANG REN GUOXING ZHONG LUNXU LIU WEN ZHU

Abnormal expression of solute carrier family 34 (sodium phosphate), member 2 (SLC34A2) in the lung may induce abnormal alveolar type II (AT II) cells to transform into lung adenocarcinoma cells, and may also be important in biological process of lung adenocarcinoma. However, at present, the effects and molecular mechanisms of SLC34A2 in the initiation and progression of lung cancer remain to be...

Journal: :International journal of oncology 2013
Ki-Eun Hwang Do-Sim Park Young-Suk Kim Byoung-Ryun Kim Seong-Nam Park Mi-Kyung Lee Seong-Hoon Park Kwon-Ha Yoon Eun-Taik Jeong Hak-Ryul Kim

The expression levels of Prx1 are frequently elevated in several human cancers, including lung cancer and may confer increased resistance to treatment. In this study, we investigated the role of Prx1 in docetaxel-induced apoptosis in A549 lung cancer cells. To test whether Prx1 knockdown affected the sensitivity of A549 cells to docetaxel treatment, we generated short hairpin RNA (shRNA) constr...

2012
Chengwei He Rong Rong Jing Liu Jianbo Wan Keyuan Zhou Jing X Kang

BACKGROUND Non-small cell lung cancer is associated with high expression of multidrug resistance (MDR) proteins and low production of reactive oxygen species (ROS). Coptis extract (COP), a Chinese medicinal herb, and its major constituent, berberine (BER), have anticancer properties. This study aims to investigate the effects of COP and BER combined with chemotherapeutic agents, including fluor...

Journal: :American journal of physiology. Lung cellular and molecular physiology 2004
S Buckley W Shi B Driscoll A Ferrario K Anderson D Warburton

Lung cancer is the most common visceral malignancy in males, with rapidly increasing incidence in females, and a devastatingly poor prognosis. Transforming growth factor (TGF)-beta has been shown to induce senescence in A549 lung cancer cells, and both TGF-beta and bone morphogenetic protein (BMP) 2 can suppress the transformed phenotype of A549 cells in vitro. We examined the effects of BMP4, ...

2017
Wei-Ting Kuo Dom-Gene Tu Ling-Yen Chiu Gwo-Tarng Sheu Ming-Fang Wu

The chemoresistance of non-small cell lung cancer (NSCLC) that occurs in docetaxel (DOC) chemotherapy substantially decreases the survival of patients. To overcome DOC-induced chemoresistance, we established DOC-selected A549 lung cancer sublines (A549/D16 and A549/D32) and revealed that both sublines were cross-resistant to vincristine (VCR) and doxorubicin (DXR). Notably, both sublines were m...

Journal: :Genetics and molecular research : GMR 2015
Y H Liu W L Zhu

In this study, we examined the effect of cetuximab (epidermal growth factor receptor monoclonal antibody) combined with afatinib (epidermal growth factor receptorand human epidermal growth factor receptor 2 tyrosine kinase irreversible inhibitor) on the apoptosis of A549 cells and on kinase domain receptor (KDR) and aquaporin 1 (AQP1) expression in A549 cells. A549 cells were cultured in RPMI-1...

2018
Yufang Zuo Dongyan Yang Yin Yu Mei Xiang Haiwen Li Jun Yang Jingjing Li Danxian Jiang Hechao Zhou Zumin Xu Zhonghua Yu

Lung cancer is a leading cause of cancer-associated mortality worldwide. The cisplatin (DDP)‑based chemotherapy remains the foundation of treatment for the majority of patients affected by advanced non‑small cell lung cancer (NSCLC). However, DDP‑resistance limits the clinical utility of this drug in patients with advanced NSCLC. The aim of the present study was to investigate the inhibitory ef...

Journal: :Acta biochimica et biophysica Sinica 2011
Wen Yan Dong Xiao Kaitai Yao

Lung adenocarcinoma is the most common type of lung cancer. A close monitor of in vivo tumor development may help to better understand the pathogenesis and pathological processes of this disease. A bimodal imaging strategy has been developed, which is a very important tool to investigate the growth and metastasis of lung adenocarcinoma. In the present study, we used a combined labeling strategy...

2018
Weipeng Hong Peiheng Cai Chuncao Xu Di Cao Weibang Yu Zhongxiang Zhao Min Huang Jing Jin

The pentose phosphate pathway (PPP), which branches from glycolysis, is correlated with cancer cell proliferation, survival and senescence. In this study, differences in the metabolic profile of the PPP and the redox status of human lung carcinoma A549 cells and cisplatin-induced multidrug-resistant A549/DDP cells were analyzed and evaluated. The results showed that A549/DDP cells exhibited dif...

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