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Phospholipase A(1) (PLA(1)) is an enzyme that hydrolyzes phospholipids and produces 2-acyl-lysophospholipids and fatty acids. This lipolytic activity is conserved in a wide range of organisms but is carried out by a diverse set of PLA(1) enzymes. Where their function is known, PLA(1)s have been shown to act as digestive enzymes, possess central roles in membrane maintenance and remodeling, or r...

Background: Mycobacterium tuberculosis is a major cause of mortality and morbidity worldwide. Infection with this bacterium is known to induce the development of autoantibodies of which a few are also known to be diagnostic markers for some other diseases. Antineutrophil Cytoplasmic Antibodies (ANCA's) are among those autoantibodies used in clinical setting for diagnosing systemic vasculitic sy...

Background: There is an ongoing debate about the validity of the A1 criterion of PTSD. Whereas the DSM-5 has opted for a more stringent A1 criterion, the ICD-11 will leave it out as a key criterion. Objective: Here we investigated whether formal DSM-IV-TR traumatic (A1) and stressful (non-A1) events differ with regard to PTSD symptom profiles, and whether there is a gender difference in this re...

The cell plasma membrane contains specialized microdomains called lipid rafts which contain high amounts of sphingolipids and cholesterol. Lipid rafts are involved in a number of membrane protein functions. The urea transporter UT-A1, located in the kidney inner medullary collecting duct (IMCD), is important for urine concentrating ability. In this study, we investigated the possible role of li...

syntax n ∈ Num x ∈ Var a ∈ Aexp a ::= n | x | a1 + a2 | a1 * a2 | a1 a2 Semantic domains Integer = {... -3, -2, -1, 0, 1, 2, 3 ...} Truth-Value = {true, false} State = Var → Integer Semantic valuation functions N: Num → Integer A: Aexp → State → Integer A [[n]] = λs. N [[n]] A [[x]] = λs. s x A [[a1 + a2]] = λs. A [[a1]] s + A [[a2]] s A [[a1 * a2]] = λs. A [[a1]] s * A [[a2]] s 6 Prolog and Au...

For integers a1, . . . , an > 0 and k > 1, let Lk+2(a1, . . . , an) denote the set of permutations of {1, . . . , a1 + · · · + an} whose descent set is contained in {a1, a1 + a2, . . . , a1+ · · ·+an−1}, and which avoids the pattern 12 . . . (k+2). We exhibit some bijections between such sets, most notably showing that #Lk+2(a1, . . . , an) is symmetric in the ai and is in fact Schur-concave. T...