OBJECTIVE To report our experience with open dismembered pyeloplasty for uretero-pelvic junction obstruction. METHODS Retrospective study was conducted in the Department of Urology, Jinnah Postgraduate Medical Centre, Karachi for a period of five and half years from May, 2006 to December, 2011. All patients with uretero-pelvic junction obstruction were entered into a database to record patien...

Objective: An abnormal filtration fraction due to divergence between glomerular filtration rate (GFR) and effective renal plasma flow (ERPF) may lead to different estimations of absolute renal function, depending on the radiopharmaceutical administered. The purpose of this study was to estimate GFR and ERPF by measuring the clearances of technetium-99m diethylenetriamine pentaacetic acid (99mTc...

OBJECTIVE To derive the ethnic factor and validate the modified estimated Glomerular Filtration Rate (eGFR) by Modification of Diet in Renal Disease (MDRD) equation for Chronic Kidney Disease (CKD) patients of Rawalpindi. STUDY DESIGN Cross- sectional study. PLACE AND DURATION OF STUDY Armed Forces Institute of Pathology (AFIP), Rawalpindi, from July 2011 to July 2012. METHODOLOGY A total...

OBJECTIVE To assess early nephrotoxicity of CDDP (Cis-diamminedichloroplatinum) manifested by a decline in the glomerular filtration rate (GFR) estimated by plasma two sample clearance method (PSC 2) after 99mTc-DTPA injection. STUDY DESIGN Descriptive study. PLACE AND DURATION OF STUDY Department of Nuclear Medicine, Karachi Institute of Radiotherapy and Nuclear Medicine, Karachi, from Sep...

We tested the hypothesis that an increased epithelial permeability may affect sites other than the intestine in patients with Crohn's disease by simultaneously evaluating their pulmonary and intestinal permeability. Pulmonary and intestinal permeability were measured by clearance of inhaled technetium-99m diethylene triamine pentacetate (99mTc-DTPA) and by urinary recovery of chromium-51 ethyle...

Aging and lung disease are recognized factors that increase mortality risk in subjects exposed to ambient particulate matter (PM). In an effort to understand the mechanisms of enhanced susceptibility, the present study examined an inbred mouse model of senescence to 1) determine changes in lung permeability as animals approach the end-of-life and 2) characterize age-dependent changes in lung me...