نتایج جستجو برای: 90y ibritumomab tiuxetan

تعداد نتایج: 879  

Journal: :Cancer research 1991
D A Vallera H Schmidberger D J Buchsbaum P Everson D C Snover B R Blazar

A monoclonal antibody recognizing Ly1, the murine homologue of CD5, was labeled with 90Y. In vivo biodistribution studies showed that 90Y-anti-Ly1 selectively localized in lymphoid tissue. Groups of B10,BR mice (H-2k) were lethally irradiated and given major histocompatibility complex-disparate C57BL/6 (H-2b) bone marrow and spleen cells to induce graft-versus-host disease (GVHD). Eight days la...

Journal: :Nuclear medicine review. Central & Eastern Europe 2013
Jolanta Kunikowska Adam Bajera Magdalena Sawicka Piotr Czwarnowski Bożena Pawłowicz Dariusz Aksamit Dariusz Pawlak Leszek Królicki

BACKGROUND Neuroendocrine tumors (NETs) are a heterogeneous group of neoplasms derived from endocrine stem cells.These tumors are characterized by overexpression of somatostatin receptors (SSTR), which is utilized for imaging using SSTR analogs. Peptide receptor radionuclide therapy (PRRT) somatostatin analogs labeled with 90Y and 177Lu in neuroendocrine tumors (NETs) results in symptomatic imp...

2014
Johnnie J. Orozco Ethan R. Balkin Ted A. Gooley Aimee Kenoyer Donald K. Hamlin D. Scott Wilbur Darrell R. Fisher Mark D. Hylarides Mazyar Shadman Damian J. Green Ajay K. Gopal Oliver W. Press John M. Pagel

Radioimmunotherapy (RIT) for treatment of hematologic malignancies has primarily employed monoclonal antibodies (Ab) labeled with 131I or 90Y which have limitations, and alternative radionuclides are needed to facilitate wider adoption of RIT. We therefore compared the relative therapeutic efficacy and toxicity of anti-CD45 RIT employing 90Y and 177Lu in a syngeneic, disseminated murine myeloid...

Journal: :Cancer research 1990
Y C Lee L C Washburn T T Sun B L Byrd J E Crook E C Holloway Z Steplewski

Monoclonal antibody CO17-1A, which has specificity for colorectal and pancreatic carcinomas, was radiolabeled with the pure beta emitter, 90Y, by either the cyclic diethylenetriaminepentaacetic acid (DTPA) anhydride technique or by a site-specific bifunctional chelate technique using 1-(p-aminobenzyl)DTPA (p-NH2-Bz-DTPA). Female nude mice bearing SW 948 human colorectal carcinoma xenografts wer...

Journal: :Cancer research 1988
R M Sharkey F A Kaltovich L B Shih I Fand G Govelitz D M Goldenberg

Monoclonal antibodies (MAbs) to carcinoembryonic antigen (CEA) or alpha-fetoprotein (AFP) were conjugated with diethylenetriaminepentaacetic acid and radiolabeled with 90Y at a specific activity of 4.0-6.0 mCi/mg. Approximately 50% of the radiolabeled anti-CEA antibody (90Y-labeled NP-2) bound to an immunoadsorbent containing CEA while analysis by high performance liquid chromatography revealed...

Journal: :Annals of the rheumatic diseases 1983
V Kyle B L Hazleman E P Wraight

Twenty-eight knees with chronic arthritis and effusion were treated with intra-articular 90Y. Synovial activity was assessed by measuring 99mTc pertechnetate uptake. There was a significant difference in uptake between controls and patients. Those who had a good response to 90Y (15 patients) showed a significant decrease in uptake, not seen in those who failed to respond. The pattern of 90Y dis...

2014
Rebecca A Dumont Daniela Seiler Nicolas Marincek Philippe Brunner Piotr Radojewski Christoph Rochlitz Jan Müller-Brand Helmut R Maecke Matthias Briel Martin A Walter

We aimed to explore the effects of 90Y-DOTATOC and 90Y-DOTATOC plus 177Lu-DOTATOC on survival of patients with metastasized gastrinoma. Patients with progressive metastasized gastrinoma were treated with repeated cycles of 90Y-DOTATOC or with cycles alternating between 90Y-DOTATOC and 177Lu-DOTATOC until tumor progression or permanent toxicity. Multivariable Cox regression analyses were used to...

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