Pancreatic ductal adenocarcinoma (PDA) is a lethal disease with a characteristic pattern of early metastasis, which is driving a search for biomarkers that can be used to detect the cancer at an early stage. Recently, the actin-associated protein palladin was identified as a candidate biomarker when it was shown that palladin is mutated in a rare inherited form of PDA, and overexpressed in many...

In knowledge engineering research the refinement of manually developed intelligent systems is still one of the key issues. Since scoring rules are an intuitive and easy to implement knowledge representation they are suitable for the manual development of knowledge bases. In this paper, we present a conservative and a creative strategy for the refinement of scoring rule bases adapting existing r...

LEVEL 1 Frequency GA DA MA N2T N2R MV TD (Hz) (dB) (dB) (dB@Hz) (×10−3) (×10−3) (×10−3) (ratio) 50 33.6 41.0 [email protected] 22.1 4.0 19.3 1.04 55 33.2 37.7 [email protected] 21.8 4.2 21.6 1.04 60 32.9 35.8 [email protected] 20.6 4.4 21.2 1.03 65 33.1 34.7 [email protected] 17.2 4.4 18.3 1.02 70 33.3 34.1 [email protected] 12.4 4.3 19.1 1.02 75 33.8 33.6 [email protected] 10.9 4.2 20.0 1.02 80 34.0 33.1 [email protected] 14.4 4.0 21.5 1.04 85 33.8 32.5...