Lori Haase, Nathaniel J. Thom, Akanksha Shukla, Paul W. Davenport, Alan N. Simmons, Martin P. Paulus, and Douglas C. Johnson Department of Psychiatry, University of California, Warfighter Performance Department, Navel Health Research Center, San Diego, CA, Department of Applied Health Science, Wheaton College, Wheaton, IL, Department of Physiological Sciences, University of Florida, Gainesville...

Irmgard Tegeder1,2,10, Michael Costigan1,10, Robert S Griffin1, Andrea Abele2, Inna Belfer3,4, Helmut Schmidt2, Corina Ehnert2, Jemiel Nejim4,9, Claudiu Marian2, Joachim Scholz1, Tianxia Wu4, Andrew Allchorne1, Luda Diatchenko5, Alexander M Binshtok1, David Goldman3, Jan Adolph2, Swetha Sama5, Steven J Atlas7, William A Carlezon8, Aram Parsegian8, Jörn Lötsch2, Roger B Fillingim6, William Maixn...

Sébastien Jacquemont,* Aurore Curie,* Vincent des Portes, Maria Giulia Torrioli, Elizabeth Berry-Kravis, Randi J. Hagerman, Feliciano J. Ramos, Kim Cornish, Yunsheng He, Charles Paulding, Giovanni Neri, Fei Chen, Nouchine Hadjikhani, Danielle Martinet, Joanne Meyer, Jacques S. Beckmann, Karine Delange, Amandine Brun, Gerald Bussy, Fabrizio Gasparini, Talita Hilse, Annette Floesser, Janice Brans...

Core planar cell polarity (PCP) proteins are well known to regulate polarity in Drosophila and vertebrate epithelia; however, their functions in vertebrate morphogenesis remain poorly understood. In this study, we describe a role for PCP signaling in the process of apical constriction during Xenopus gastrulation. The core PCP protein Vangl2 is detected at the apical surfaces of cells at the bla...

Correspondence to Stuart A. Aaronson: [email protected] Abbreviations used in this paper: CM, conditioned medium; dnTCF4, dominantnegative TCF4; ERK, extracellular receptor-dependent kinase; HA, hydroxyapatite; hMSC, human MSC; MSC, mesenchymal stem cell; Osx, osterix; PCNA, proliferating cell nuclear antigen; shRNA, short hairpin RNA; TCF, T cell factor; TCP, tri-Ca phosphate. Introduction

Alexis L. Beatty, MD, MAS; Ivy A. Ku, MD, MAS; Kirsten Bibbins-Domingo, PhD, MD; Robert H. Christenson, PhD; Christopher R. DeFilippi, MD; Peter Ganz, MD; Joachim H. Ix, MD, MAS; Donald Lloyd-Jones, MD, MSc; Torbjørn Omland, MD, PhD, MPH; Marc S. Sabatine, MD, MPH; Nelson B. Schiller, MD; Michael G. Shlipak, MD, MPH; Hicham Skali, MD, MSc; Madoka Takeuchi, MS; Eric Vittinghoff, PhD; Mary A. Who...

The expression level of inhibitor of DNA binding 2 (Id2) is increased in colorectal carcinomas and is positively correlated with poor prognosis. However, the functional significance of Id2 in intestinal tumorigenesis has not been fully defined using genetic approaches. Here, we show that Id2 promotes ileal tumor initiation in Apc-deficient mice. Expression of Id2 was stimulated by Wnt signaling...

The current view of skeletal patterning fails to explain the formation of sesamoid bones. These small bones, which facilitate musculoskeletal function, are exceptionally embedded within tendons. Although their structural design has long puzzled researchers, only a limitedmodel for sesamoid bone development has emerged. To date, sesamoids are thought to develop inside tendons in response to mech...

Analysis of transcription at the level of single cells in prokaryotes and eukaryotes has revealed the existence of heterogeneities in the expression of individual genes within genetically homogeneous populations. This variation is an emerging hallmark of populations of Embryonic Stem (ES) cells and has been ascribed to the stochasticity associated with the biochemical events that mediate gene e...

Introduction Cardiac excitation–contraction coupling is a transduction cascade that results in muscle contraction and relaxation. In ventricular myocytes, the arrival of an action potential activates sarcolemmal L-type Ca channels, and the subsequent inward Ca current, in turn, activates several RyRs in the SR membrane (the Ca release unit [CRU]). Activation of a CRU causes more Ca to be releas...