Urocanic acid (UCA) is a major UV chromophore in the upper layers of the skin where it is found predominantly as the trans isomer. UV irradiation induces photoisomerisation of trans-UCA to cis-UCA which has been shown to mimic some of the immunosuppressive properties of UV exposure. We examined the wavelength dependence for trans-UCA to cis-UCA photoisomerisation in vitro and in mouse skin in v...

Identification of rigid counterparts for common flexible scaffolds is crucial to the advancement medicinal chemistry. Herein, synthesis new bicyclo[2.1.1]hexanes act as rigidified cyclopentanes described.

1. A.M. Weiner, and A.M. Kan'an, "Femtosecond pulse shaping for synthesis, processing, and time-to-space conversion of ultrafast optical waveforms," IEEE J. of Selec. Top. in Quant. Electron., 4, 317 (1998). 2. M.A. Krurnbügel et al., "Ultrafast optical switching by use of fully phase-matched cascaded second-order nonlinearities in a polarization-gate geometery," Opt. Lett., 22, 245 (1997). 3. ...

A series of diverse natural product-like structures have been synthesised by the use of a number of novel transannulation reactions across a cyclononene ring. Transannular cyclisations through oxygen functionality have generated a number of bicyclo[5.3.1]systems containing bridged cyclic ethers and bicyclo[5.2.2]lactones, as well as a tetrahydrofuran-containing bridged analogue of hexacyclinic ...

Based on both preclinical findings and anecdotal evidence in man, the psychoactive indole alkaloid ibogaine has been suggested to have anti-addictive properties. Previous studies indicate that blockade of NMDA receptors may mediate at least some of the putative anti-addictive actions of ibogaine. The potencies of a series of ibogaine analogs to inhibit (+)-[3-3H]5-methyl-10,11-dihydro-5H-dibenz...