perazinyl)-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid] (Fig. 1) is a broad spectrum fluoroquinolone antibacterial, which is effective against a wide range of Gram-positive and Gram-negative bacteria (1). Fluoroquinolones are sensitive to light (2) and studies have been carried out on the photodegradation of quinolones (3), fluoroquinolones (4), ciprofloxacin (5, 6), sparfloxaci...

Reaction of thionyl chloride with 7-chloro-1-cyclopropyl-6-fluoro-1,4-dihydro-4- oxoquinoline-3-carboxylic acid 1 gave acid chloride 2. Compound 2 was reacted with glycine and D-glutamic acid to afford 2-(7-chloro-1-cyclopropyl-6-fluoro-4-oxo-1,4- dihydroquinoline-3-carbonyl) aminopantandioicacid 3a and 2-(7-chloro-1-cyclopropyl-6- fluoro -4- oxo-1,4-dihydroquinoline-3-carbonyl)aminoacetica...

We discovered on the chromosome of Saccharomyces cerevisiae Sigma 1278b novel genes involved in L-proline analogue L-azetidine-2-carboxylic acid resistance which are not present in the standard laboratory strains. The 5.4 kb-DNA fragment was cloned from the genomic library of the L-azetidine-2-carboxylic acid-resistant mutant derived from a cross between S. cerevisiae strains S288C and Sigma 12...

With more and more organometallic compounds receiving attention for applications in medicinal organometallic chemistry, the need arises for stereoselective syntheses of more complicated structures containing organometallic moieties, for example as isosteric substitutes for organic drug candidates. Herein, the synthesis and characterization of both diastereomers of a planar chiral (η(6)-arene)Cr...

The stereoselective synthesis of (1S,2S,5R)-5-((4-methoxybenzyl)oxy)-2-methyl-8-methylene-1,2,4a,5,6,7,8,8a-octahy-dronaphthalene-1-carboxylic acid (2) is described, which comprises the bicyclic core structure natural product amycolamicin (1). ring-system was established via an intramolecular Diels-Alder reaction a triene carrying SuperQuat chiral auxiliary. latter could be readily removed by m...

Flash photolysis of 10-diazo-9(10H)-phenanthrenone in aqueous solution was found to give two successively formed transient species and to produce fluorene-9-carboxylic acid as the major reaction product. These transients were identified, through solvent isotope effects and the form of acid-base catalysis, as fluorenylideneketene, formed by photo-Wolff reaction of the diazophenanthrenone, and fl...

Five new spiro[indoline-3,3′-indolizine]s have been synthesized with high regio- and stereospecificity in one-pot three-component reactions between a substituted indole-2,3-dione, ( S )-pipecolic acid trans -3-benzoylacrylic acid, subsequently characterized using combination of elemental analysis, IR 1 H 13 C NMR spectroscopy, mass spectrometry crystal structure analysis. (1′ SR ,2′ ,3 RS ,8a′ ...

The hydro-thermal reaction of butane-1,2,3,4-tetra-carboxylic acid (H(4)butca), 4,4'-bipyridine (bipy) and Mn(SO(4))(2)·H(2)O afforded a new co-crystal, C(8)H(10)O(8)·2C(10)H(8)N(2) or H(4)butca·2(bipy), in which strong O-H⋯N hydrogen-bonding and weak π-π stacking [centroid-centroid distance = 3.8459 (19) Å] inter-actions assemble the organic mol-ecules into a three-dimensional supra-molecular ...

The title compound, C(12)H(9)Cl(2)NO(2), was prepared by the esterification of 3,7-dichloro-quinoline-8-carboxylic acid with triethyl phosphite. The crystal structure is stabilized by aromatic π-π stacking between the benzene and the pyridine rings of neighbouring mol-ecules [centroid-centroid distances = 3.716 (2) and 3.642 (2) Å]. In addition, weak inter-molecular C-H⋯N hydrogen bonds are pre...