TCR and cytokine signals induce naive T cells to undergo spontaneous divisions as part of a homeostatic response to conditions of T cell deficiency. The conditions under which these signals evoke the homeostatic response and their interaction with each other are poorly understood, and yet are very important clinically in considering strategies for immune reconstitution. Here, we show that p56(l...

The existence of a common lymphoid progenitor that can only give rise to T cells, B cells, and natural killer (NK) cells remains controversial and constitutes an important gap in the hematopoietic lineage maps. Here, we report that the Lin(-)IL-7R(+)Thy-1(-)Sca-1loc-Kit(lo) population from adult mouse bone marrow possessed a rapid lymphoid-restricted (T, B, and NK) reconstitution capacity in vi...

Based on existing literature, this article makes a case for open (government) data as supporting political efficiency, socio-economic innovation and administrative efficiency, but also finds a lack of measurable impact. It attributes the lack of impact to shortcomings regarding data access (must be efficient) and data usefulness (must be effective). To address these shortcomings, seven key acti...

A closed Riemannian n-manifold M with Ricci M > n 1 has diameter < 7r ([M]), and equality holds only if M is isometric to the unit sphere S ~ ([Cn]). Given these results, it is natural to ask whether M is diffeomorphic to S n if the diameter of M is almost 7r. This question was answered negatively by Anderson and Otsu, who showed that even the topology of such a space can be different from the ...

Chlordane was a most used as insecticide by farmers. Today, it is banned owing to its toxicity, bio-accumulative and persistence properties. Since then ¶tits prohibition has created more unexploited stocks in the environment. ¶In order still allow use of these products, we theoretically proposed new molecules derived from it. To meet this objective, have reduced number chlorine atoms chlordan...

In this paper, we investigate m-DCI and m-CI properties of dihedral groups. We show that for any m E {I, 2, 3}, the dihedral group D2k is m-DCI if and only if D2k is m-CI if and only if 2 f k. § 1. Preliminaries Let G be a finite group and 5 a subset of G with 1 1:. 5. We use r = Cay( G; 5) to denote the Cayley digraph of G with respect to 5, defined to be the directed graph with vertex set and...

Cysteine proteases (gingipains) from Porphyromonas gingivalis are key virulence factors in chronic periodontitis. Innate immune receptors CD14, Toll-like receptor (TLR) 2 and TLR4 are important in P. gingivalis recognition. We examined the ability of gingipains to cleave CD14, TLR2 and TLR4, and the consequences for the cellular response to bacterial challenge. Macrophages were exposed to Arg (...