FBI-1 is a cellular POZ-domain-containing protein that binds to the HIV-1 LTR and associates with the HIV-1 transactivator protein Tat. Here we show that elevated levels of FBI-1 specifically stimulate Tat activity and that this effect is dependent on the same domain of FBI-1 that mediates Tat-FBI-1 association in vivo. FBI-1 also partially colocalizes with Tat and Tat's cellular cofactor, P-TE...

New imidazole ring derivatives comprising 1,3-oxazoline, Schiff's bases, thiadiazole, oxadiazole and 1,2,4-triazole moieties are reported. 3-Aminobiimidazol-4-one compounds 7a-c were synthesized by the reaction of compounds 6a-c with hydrazine hydrate. Biimidazole esters 9a-c were converted into biimidazole hydrazide esters 10a-c. Compounds 7a-c and 10a-c were converted into a variety of deriva...

myelodysplastic syndrome (mds), is a group of heterogeneous disorders of hematopoietic stem cell colonies which is determined by incomplete hematopoiesis in one or more cell lines. the incidence increases with age and it has less been reported among patients under 50 years of age. the commonest form of mds is sporadic, and familial occurrence of mds is rare. patients with familial mds are young...

The estrogen 17β‑estradiol has been proven to serve an indispensable role in the occurrence and development of adenomyosis (ADS). let‑7a/Lin28B axis can control cell proliferation by acting as a tumor‑inhibiting numerous types cancer. However, its ADS remains unknown. present study aimed i) elucidate let‑7a regulating human uterine junctional zone (JZ) smooth muscle cells (SMCs) ADS, ii) evalua...

Myelodysplastic syndrome (MDS), is a group of heterogeneous disorders of hematopoietic stem cell colonies which is determined by incomplete hematopoiesis in one or more cell lines. The incidence increases with age and it has less been reported among patients under 50 years of age. The commonest form of MDS is sporadic, and familial occurrence of MDS is rare. Patients with familial MDS are young...

To locate the genes controlling adaptability in bread wheat using AMMI (additive main effect and multiplicative interaction) model, twenty-one substitution lines derived from the parents Chinese Spring (recipient) and Chayan (donor) were used in a randomized complete block design with three replications in three different environments in the Agricultural College of Razi University, Kermanshah, ...

We report on the relationship between the structure-pharmacokinetics, metabolism, and therapeutic activity of semisynthetic bile acid analogs, including 6a-ethyl-3a,7a-dihydroxy-5b-cholan-24-oic acid (a selective farnesoid X receptor [FXR] receptor agonist), 6a-ethyl-23(S)-methyl-3a,7a,12a-trihydroxy-5b-cholan-24-oic acid (a specific Takeda G protein–coupled receptor 5 [TGR5] receptor agonist),...