We read carefully the very interesting article by Jones et al. (1), which appears in the latest issue of the Journal. To our surprise, we realized that, during the determination of opiates in blood, although the described derivatization procedure involves BSTFA, the authors use, for their qualitative and quantitative analysis, mass fragments that correspond to their pentafluoroderivatives and t...

To study the short-term effects of theophylline on sleep and wakefulness, 24 healthy men and women, aged 21 to 35 years, received each of three doses, 0, 3, and 6 mg/kg, of theophylline double-blind in a Latin Square design, administered to 12 subjects at 9 AM and to the other 12 at 11 PM. After the daytime administration, sleep latency was tested at 10 AM, 12 Noon, 2 PM, and 4 PM and divided a...

Jarrar, Doraid, Joachim F. Kuebler, Loring W. Rue, III, Sadis Matalon, Ping Wang, Kirby I. Bland, and Irshad H. Chaudry. Alveolar macrophage activation after trauma-hemorrhage and sepsis is dependent on NFB and MAPK/ERK mechanisms. Am J Physiol Lung Cell Mol Physiol 283: L799–L805, 2002; 10.1152/ajplung.00465.2001.—The acute respiratory distress syndrome (ARDS) is a major cause of morbidity aft...

The acidity constants of some amino acids (Am) were determined by potentiometric pH titration. The stability constants of the 1:1 complexes formed between M2+: Ca2+, Mg2+, Mn2+, Co2+, Ni2+, Cu2+ or Zn2+ and Am2-, were determined by potentiometric pH titration in aqueous solution (I = 0.1 M, NaNO3, 25°C). The order of the stability constants was reported. It is shown that the stability of the bi...

The in vitro antibacterial activity of AM-1155 against a wide variety of clinical isolates was compared with those of other fluoroquinolones. The MICs of AM-1155 for 90% of Staphylococcus aureus, Streptococcus pneumoniae, and Enterococcus faecalis isolates tested were 0.10, 0.39, and 0.78 microgram/ml, respectively. The antibacterial activity of AM-1155 against gram-positive bacteria and anaero...

analyses and thermal infrared channels 4 and 5 NOAA- AVHRR images. This research was carried out in Lut Desert located in center of sub-tropical divergence dominant in' Iranian plateau. The physical and thermal properties of the various desert surfaces have been determined using correlation relationships between the desert variables including: dark sand, normal sand, marl, saline soil, soil dep...

Four novel oxapenem compounds (i.e., AM-112, AM-113, AM-114, and AM-115) were investigated for their beta-lactamase inhibitory activity against a panel of isolated class A, C, and D enzymes, which included expanded-spectrum beta-lactamase enzymes (ESBLs). The oxapenems were potent beta-lactamase inhibitors. Activity varied within the group, with AM-113 and AM-114 proving to be the most active c...

Ligand field splittings were extracted from absorption spectra of metal hexacarbonyl and hexacyano complexes over 35 years ago by Gray and coworkers (J. Am. Chem. Soc., 85, 2922 (1963); ibid. 90, 4260, 5713 (1968)). Recent time-dependent density functional theory calculations by Baerends and coworkers (J. Am. Chem. Soc., 121, 10356 (1999)) on M(CO)6 with M1⁄4Cr, Mo, W raised questions about the...

Calcitonin gene-related peptide (CGRP), adrenomedullin (AM), and amylin are structurally related peptides mediating vasorelaxation in the coronary circulation possibly via CGRP receptors (subtypes 1 or 2). Functional CGRP1 receptors appear to consist of at least three different kinds of proteins: the calcitonin receptor-like receptor (CRLR), receptor-activity-modifying proteins (RAMPs) and the ...