Omjyoti Dutta, Mariusz Gajda, Philipp Hauke, Maciej Lewenstein, Dirk-Sören Lühmann, Boris A. Malomed, Tomasz Sowiński, and Jakub Zakrzewski 1 Instytut Fizyki imienia Mariana Smoluchowskiego, Uniwersytet Jagielloński, Reymonta 4, 30-059 Kraków, Poland 2 Institute of Physics of the Polish Academy of Sciences, Al. Lotników 32/46, PL-02-668 Warsaw, Poland 3 Center for Theoretical Physics of the Pol...

To explain the sequence-dependent in vitro cytotoxic synergism between 4-hydroperoxycyclophosphamide (4-HC) and cisplatin in the K-562 human leukemia cell line, we have hypothesized that 4-HC decreases cellular glutathione (GSH) levels and that the resulting diminution of the cellular protective effect of GSH leads to the increased cytotoxicity of cisplatin. Exposure of K-562 cells to 4-HC resu...

We investigated the mechanism of cell growth inhibition caused by the deoxyribonucleosides thymidine (dThd), deoxyguanosine (dGuo), deoxyadenosine (dAdo), and deoxycytidine (dCyd). Growth of the cultured human leukemic cells HL-60 and K-562 was measured by cloning in soft agar. Of the deoxyribonucleosides, dGuo was the most potent cell growth inhibitor; however, the potency of added dAdo was pr...

The mechanisms of cytotoxicity, cellular drug uptake, intracellular drug distribution, cellular pharmacokinetics, formation of arabinofuranosylcytosine triphosphate (ara-CTP), and DNA incorporation of N4-hexadecyl-1-beta-D-arabinofuranosylcytosine (NHAC), a new lipophilic derivative of arabinofuranosylcytosine (ara-C) formulated in small unilamellar liposomes, were determined in vitro in the hu...

06_352-5 28/[152-159) 8 006-016 [160-168) 9 016-033 [168-176) 3 3 1 033-044 [176-183) 10 6 3 4 044-059 [183-192) 20 17 1 6 059-073 [192-200) 8 20 1 5 073-086 [200-208) 2 14 1 086-101 [208-217) 25 27 24 101-115 [217-225) 17 29 11 12 115-116 [225-234) 4 1 132-142 [234-243) 36 3 142-156 [243-252) 27 42 5 8 156-171 [252-261) 3 37 7 2 171-185 [261-270) 12 48 4 1 185-198 [270-278) 124 30 2 2 199-212 ...

The spread of the interest and the need for process reference models, specifically for small and medium software development organizations, has been a catalyst for generating ISO/IEC 29110 Software Engineering — Lifecycle profiles for Very Small Entities. Based on the Mexican standard NMX-I-059-NYCE-2005, better known as MoProSoft, ISO/IEC 29110 is the first international standard specifically ...

This article provides a brief analysis of the Court Justice EU decision 16 March 2021, C 562/19 P European Commission v Republic Poland, addressing issues state aid and progressive turnover taxation.

background and objectives: ziziphora clinopodioides is a perennial herb and grows widely in west and northwest of iran. the aerial parts are used as appetizer, carminative and antiseptic as well as for the treatment of medical conditions such as high blood pressure, asthma hyperhidrosis, palpitation and insomnia methods: the aerial parts of ziziphora clinopodioides lam. were extracted by ethano...