نتایج جستجو برای: 50 lethality

تعداد نتایج: 466750  

Journal: :Journal of laboratory and precision medicine 2023

Background: No definitive epidemiological evidence is available on SARS-CoV-2 lethality during the surge of different variants concern (VoCs) and coronavirus disease 2019 (COVID-19) vaccination in relation to common flu fatality.

Journal: :Pharmacology, biochemistry, and behavior 1991
K A Trujillo H Akil

Interactions between excitatory amino acids and opioids were examined by studying the ability of the noncompetitive N-methyl-D-aspartate (NMDA) receptor antagonist MK-801 to affect morphine catalepsy and lethality. MK-801 (0.3 mg/kg) reduced the ED50 for morphine-induced catalepsy from approximately 30 mg/kg to less than 10 mg/kg, and reduced the LD50 for morphine from approximately 100 mg/kg t...

M. Mirzaei M.B. Bahadori

Background and objectives: Salvia species are important because of their medicinal, traditional and economical uses. They are used traditionally for treatment of several diseases. The genus Salvia is represented in the Iranian flora by 61 species of which, 17 are endemic.  In the present study, the phytochemical and biological effects of two Iranian Salvia species hav...

Journal: :Proceedings of the National Academy of Sciences 2011

2009
G. UGAZIO P. A. MILILLO V. Vannini A. Calligaro

treatment with carbenoxolone sodium resulted in thc increase of free and bound sialic acids to those values found in normal subjects, but no increase above control values was observed. The work now reported shows that treatment of normal adult rats with carbenoxolone results in significant increases in a number of components of the gastric mucus and mucosa. This may be related to the mechanism ...

Journal: :Bioorganic & medicinal chemistry letters 2012
Rachid Skouta Miki Hayano Kenichi Shimada Brent R Stockwell

A series of Pictet-Spengler condensation derivatives (tetrahydro-β-carbolines) was designed, synthesized and evaluated for lethality against a panel of seven cancer cell lines. Seven compounds (2a, 13, 20, 21, 27, 29 and 34) showed lethality in at least five cell lines. Among these, compound 27 showed a unique selectivity towards oncogenic-RAS expressing BJ-TERT/LT/ST/RAS(V12) tumor cells, comp...

Journal: :Cancer research 1976
C E Myers R C Young B A Chabner

In order to provide a more rational approach to the design of chemotherapeutic programs involving 5-fluorouracil (5-FU), the kinetic effect of this drug on bone marrow, gastrointestinal epithelium, and tumorous tissues in mice was monitored by determining the rate of incorporation of labeled deoxyuridine (UdR) into DNA following doses of 15, 50, and 100 mg/kg i.p: In BALB/c x DBA/2 F1 (hereafte...

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