OBJECTIVE to determine if misoprostol is safe and efficacious in preventing postpartum haemorrhage (PPH) when administered by trained traditional birth attendants (TBA) at home deliveries. DESIGN a randomised, double-blind, placebo-controlled trial. SETTING Chitral, Khyber Pakhtunkhwa Province, Pakistan. POPULATION a total of 1119 women giving birth at home. METHODS from June 2006 to Ju...

BACKGROUND AND PURPOSE Medical abortion was not officially approved in Taiwan until the end of 2001. We investigated the efficacy of combination mifepristone and misoprostol therapy for medical abortion (which has now been approved) in early pregnant Taiwanese women and whether the attitudes of women who received this treatment affected the clinical outcome of medical abortion. METHODS Eighty...

Berberine, an alkaloid originally extracted from the plant Coptis chinensis and other herb plants, has been used as a pharmacological substance for many years. The therapeutic effect of berberine has been attributed to its interaction with nucleic acids and blocking cell division. However, levels of berberine entering individual microbial cells minimal for growth inhibition and its effects on b...

AIM The aim of this work is to establish two simple, economical, and rapid spectrophotometric methods for the quantification of entacapone in bulk material and in tablets. Further, this study is designed to validate the developed methods as per ICH guidelines. MATERIALS AND METHODS In Methods I and II, a stock standard solution was prepared by dissolving 10 mg of entacapone in 100 mL of 10% v...

Structureactivity relationships of nine thiophenes, 2,2': 5',2″-terthiophene (1), 2-chloro-4-[5-(penta-1,3-diyn-1-yl)thiophen-2-yl]but-3-yn-1-yl acetate (2), 4-(2,2'-bithiophen-5-yl)but-3-yne-1,2-diyl diacetate (3), 4-[5-(penta-1,3-diyn-1-yl)thiophen-2-yl]but-3-yne-1,2-diyl diacetate (4), 4-(2,2'-bithiophen-5-yl)-2-hydroxybut-3-yn-1-yl acetate (5), 2-hydroxy-4-[5-(penta-1,3-diyn-1-yl)thiophen-...

Two stability indicating chromatographic methods were proposed for the determination of almotriptan, eletriptan, and rizatriptan, in presence of their acid degradation products. The first method is a quantitative densitometric thin layer chromatography. The developing systems were; acetonitrile: methanol: dichloromethane: ammonia (10:6:3:1 v/v), ethyl acetate: methanol: ammonia (15:4:1 v/v), an...

it is well known that several plant extracts have a lactogenic effect. this response may be inducedthrough the stimulation of prolactin release from lactotrope cells. a partial purification of the activecompound indicated that it is rich in pectin and β-glucan. these materials stimulate secretion of prolactinfrom hypophyseal fragments. in the present study, the effect of β-glucan on the secreti...

Some recent clinical reports have shown that the combination of oxymatrine, a phyto-derived drug, with lamivudine (3TC) could improve its curative effect against hepatitis B virus (HBV) infection. However, the experimental data in support of this combination strategy are lacking. In this study, we investigated the anti-HBV activity of the combination of 3TC and either oxymatrine or matrine on H...

The aim of the present Study was to develop a simple and rapid method for determination of metformin (MET) and glibenclamide (GLB) ) in Pharmaceutical dosage form. A high-performance liquid chromatographic, fist and second derivative spectrophotometric methods used for the simultaneous determination of MET and GLB. The first derivative amplitudes at 236 nm and 275.7 nm were selected for the ass...

OBJECTIVES To compare the efficacy and gastroduodenal safety of a fixed-dose combination of diclofenac sodium 50 mg and misoprostol 200 micrograms twice daily with those of piroxicam 10 mg twice daily and naproxen 375 mg twice daily in patients with osteoarthritis. METHODS A 4 week, randomised, double-blind, parallel-group, multicentre study was conducted in 643 patients with symptomatic oste...