The phytochemical investigation on the chloroform and ethyl acetate soluble fractions of Colebrookia oppositifolia Smith. led to the isolation of four new-source compounds namely 1pentacosanol (1), stigmast-7-ene-3β-ol (2), p-hydroxybenzoic acid (3), ursolic acid (4) and seven known compounds namely triacontane (5), triacontanol (6), betulonic acid (7), negletein (8), 5,2′,6′-trihydroxy-7-metho...

The effect of hydroxy substitution on 1,4-naphthoquinone toxicity to cultured rat hepatocytes was studied. Toxicity of the quinones decreased in the series 5,8-dihydroxy-1,4-naphthoquinone greater than 5-hydroxy-1,4-naphthoquinone greater than 1,4-naphthoquinone greater than 2-hydroxy-1,4-naphthoquinone, and intracellular GSSG formation decreased in the order 5,8-dihydroxy-1,4-naphthoquinone gr...

Morphological, chemical and genetic differences of 12 tree basil (Ocimum gratissimum L.) accessions were studied to determine whether volatile oils and flavonoids can be used as taxonomical markers and to examine the relationship between RAPDs to these chemical markers. Eugenol, thymol, and geraniol were the major volatile oil constituents found in Ocimum gratissimum. Xantomicrol and cirsimarit...

A practical synthesis of nobiletin, a polymethoxylated citrus flavone, was accomplished by utilizing our novel flavone synthesis. Synthetic nobiletin was labelled by selective demethylation and rapid incorporation of (11)C atom. Positron emission tomography images successfully visualized the brain distribution, which may provide therapeutic benefits in the treatment of Alzheimer's disease.

REFERENCE: Pinostrobin--an anti-leukemic flavonoid from Polygonum lapathifolium L. ssp. nodosum (Pers.) Dans. Information from Industry Assess clinically focused product information on Medscape. * Click Here for Product Infosites -Information from Industry. Medscape Newsletters Sign Up Sign Up To Receive Medscape Best Evidence Key journal articles ranked for newsworthiness and clinical relevanc...

The effects of potassium thiocyanate on the binding of DL-aamino-3-hydroxy-5-methylisoxazolepropionic acid (AMPA), 6-cyano-7-nitroquinoxaline-2,3-dione (CNQX), and L-glutamate to the AMPA receptor complex were studied in rat brain membranes. Thiocyanate increased the affinity of AMPA receptors for both AMPA and i.-glutamate and decreased the affinity for CNQX. Displacement of [3H]CNQX binding b...

REFERENCE: Pinostrobin--an anti-leukemic flavonoid from Polygonum lapathifolium L. ssp. nodosum (Pers.) Dans. Information from Industry Assess clinically focused product information on Medscape. * Click Here for Product Infosites -Information from Industry. Medscape Newsletters Sign Up Sign Up To Receive Medscape Best Evidence Key journal articles ranked for newsworthiness and clinical relevanc...

Several natural and synthetic flavone derivatives have been reported to inhibit formation of amyloid fibrils or to remodel existing fibrils. These studies suggest that the numbers and positions of hydroxyl groups on the flavone rings determine their effectiveness as amyloid inhibitors. In many studies the primary method for determining the effectiveness of inhibition is measuring Thioflavin T (...

Most anticancer drugs have their origin in traditional medicinal plants. We describe here a flavone, 5,3'-dihydroxy-3,6,7,8,4'-pentamethoxyflavone (PMF), from the leaves of the Thai plant Gardenia obtusifolia, that has anti-inflammatory and anticancer potential. Because the nuclear factor-κB (NF-κB) pathway is linked to inflammation and tumorigenesis, we investigated the effect of PMF on this p...