Neisseria meningitidis is the most common cause of bacterial meningitis in children and young adults worldwide. A 4-component vaccine against N. meningitidis serogroup B (MenB) disease (MenB-4C [Bexsero]; GSK) combining factor H binding protein (fHBP), neisserial heparin binding protein (NHBA), neisserial adhesin A (NadA), and PorA-containing outer membrane vesicles was recently approved for us...

The selection of a battery thermal management technique is important to overcoming safety and performance problems by maintaining the temperature batteries within desired range. In this study, LiFePO4 (LFP) pouch-type having capacity 20 Ah was experimentally cooled with both air liquid (immersion cooling) techniques. Distilled water selected as immersion fluid in experiments, impact discharge r...

The presence of biogenic amines in cultured cells of mouse neuroblastoma C-1300 (clone NB-2a) was suggested by fluorescence-microscope histochemistry. Incubation in media containing L-[14C]tyrosine and L-[14C]tryptophan for 24 h, followed by high-voltage electrophoresis, radiochromatogram scanning, and scintillation counting, conf i rmed the presence of [~4C]dopamine, [~4C]norepinephrine, [~'C]...

This paper presents a framework for generating, representing, and interacting with the line congruences associated with four general finite poses. These line congruences are the solution space of spatial 4C mechanisms which will guide a moving body through the four prescribed poses. Hence, the contributions of this paper are applicable to developing interactive tools for designing spatial 4C me...

With the goal of developing novel and potent anticancer therapies, a new set of 1,3,4-trisubstituted pyrazole derivatives linked to different heteroaryl systems at C-4 position were prepared and estimated for their anticancer effects at NCI, USA employing a two stage procedure using 60 various human tumor cell lines. Anticancer evaluation disclosed that, compound 4c displayed super fat potency ...

PAMAM dendrimer-RGD-4C peptide conjugate was synthesized and in vitro targeting efficacy to integrin receptor expressing cells was studied by flow cytometry and confocal microscopy.