Nanomedicines In article 2201140 by Hsin-Cheng Chiu and co-workers, an oral polysaccharide microgel formulation containing dual-modality therapeutic nanoparticles developed for local treatment of colon cancer is imparted to hierarchical targeting residues, leading increases in retention cell uptake nanotherapeutics. With enzymatic degradation dextran microgels occurring exclusively the colon, n...

background: considering the importance of updating information about incidence and mortality of common or fatal cancers and the need for studying the effectiveness   of   changes   in   the   iranian   cancer   registration   system   from pathological based to population based since 2007, the aim of this study was to provide updated population based information on incidence and mortality rates...

The aim of this study was to characterize the familial risk of colon and rectal cancer using 2 population-based registries in Iceland, the Icelandic Cancer Registry and a genealogy database. The standardized incidence ratio (SIR) was used to estimate the risk among relatives of colorectal cancer index cases diagnosed in Iceland over a 46-year period (1955-2000). The 2,770 colorectal cancer pati...

Cyclooxygenase (COX) is the rate-limiting enzyme in prostaglandins (PGs) biosynthesis. Previous studies indicate that COX-2, one of the isoforms of COX, is highly expressed in colon cancers and plays a key role in colon cancer carcinogenesis. Thus, searching for novel transcription factors regulating COX-2 expression will facilitate drug development for colon cancer. In this study, we identifie...

PURPOSE BARD1 is a BRCA1-binding partner with tumor suppressive properties. Aberrant splice variants of BARD1 have been detected in various cancers, and it has been postulated that the presence of some splice variants is cancer specific. This is the first study assessing BARD1 expression patterns and correlation with clinical outcome in colon cancer. EXPERIMENTAL DESIGN We analyzed colon canc...

MYH9 (myosin, heavy chain 9, non-muscle) as a gene encodes NM II-A (non-muscle II-A) protein, exists primarily in the cytoplasm. MYH9 consists of 2 mysoin heavy chains with a relative molecular mass of 230 kDa. Previous studies have shown that MYH9 is involved in a number of diseases, including cancer. However, the exact role of MYH9 in colon cancer is still unclear. Therefore, we used a tissue...

there is a good literature confirming the effects of social capital on different health domains. the increase in different types of cancer has caused scientists to encounter a number of issues regarding the reasons of affliction by this disease. the aim of this empirical research was to study the causal aspects of social capital of iranian patients with cancer.the study was a causal-comparative...

background: bax and bcl-2 are the major members of bcl-2 family whose play a key role in tumor progression or inhibition of intrinsic apoptotic pathway triggered by mitochondrial dysfunction. therefore, the balance between pro- and anti-apoptotic members of this family can determine the cellular fate. methods: in this study, the relative level of mrna expression of bax and bcl-2 genes was deter...

BACKGROUND Although data on the association of physical activity and colon cancer risk is convincing, little research has examined whether change in physical activity alters risk of cancer incidence and mortality. METHODS We examined the association of 10- and 15-year change in physical activity with risk of colon cancer incidence and mortality in the Cancer Prevention Study II. Endpoints wer...

BACKGROUND As a disease with extremely complex molecular mechanisms, many deregulated miRNAs have been identified in colon cancer. Few studies have been performed by using Ingenuity Pathways Analysis (IPA) to predict miRNAs specifically expressed in colon cancer. METHODS A characteristic microRNA-target network of colon cancer was explored using IPA. Then the clinical significance of miR-19b-...