It is shown that the concept of a Universal Computer cannot be realized. Specifically, instances of a computable function F are exhibited that cannot be computed on any machine U that is capable of only a finite and fixed number of operations per step. This remains true even if the machine U is endowed with an infinite memory and the ability to communicate with the outside world while it is att...

In pregnancy period, there is high risk of hepatic diseases and alcohol consumption increases such risk. Some pregnant mothers are not able to quit the habit of drinking alcohol or they are unaware of its dangers. Finding a drug which is effective and efficient in reducing ethanol misuse consequences during pregnancy can assist the decrease of harmful effects of this habit. The purpose of the c...

Human herpesvirus 8 (HHV-8; Kaposi sarcoma-associated herpesvirus)-specific cytotoxic T-lymphocyte (CTL) and interferon-gamma (IFN-gamma) responses to proteins produced during the lytic cycle of HHV-8 replication are mediated by HLA class I-restricted, CD8(+) T cells. We have characterized the fine specificity of the CD8(+) T-cell response to 25 peptides derived from 5 HHV-8 lytic cycle protein...

A tabulation of carcinogenic potency (TD50) by species for 492 chemicals that induce tumors in rats or mice is presented. With the use of the Carcinogenic Potency Database, experimental results are summarized by indicating in which sex-species groups the chemical was tested and the respective evaluations of carcinogenicity. A comparison of three summary measures of TD50 for chemicals with more ...

Transforming growth factor beta (TGFbeta) is known to exert both positive and negative effects on different stages of tumor formation. Of the TGFbetaisoforms, TGFbeta1 is highly expressed in prostate cancer and leads to tumor promotion and metastasis. Increased expression of TGFbeta1 is associated with more aggressive tumors and poor prognosis. Several polymorphisms in TGFB1 have been identifie...

Colorectal cancer (CRC) is one of the most common cancers worldwide with high mortality rates. MicroRNAs (miRNAs) have an established role in the development of different cancers. Single nucleotide polymorphisms (SNPs) in miRNA related genes were linked with various gastrointestinal malignancies. However, the data on association between miRNA SNPs and CRC development are inconsistent. The aim o...

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Legionella is an opportunistic pathogen with a biphasic life cycle that occasionally infects humans. The aim of the study was to assess distribution virulence genes and genetic diversity among L. pneumophila isolated from water supply systems residential buildings in Latvia. In total, 492 samples 200 were collected. Identification spp. performed according ISO 11731, 58 isolates subjected whole-...

During the last decade, many companies considered to implement RFID technology in their supply chains. They had to choose from a variety of largely incompatible RFID systems and therefore demanded RFID standardization. Only common RFID systems along the supply chain were expected to deliver the substantial benefits. This paper describes the RFID pilot and roll-out by German fashion retailer Kau...