Quinazolinones is an important chemical synthesis with different physiological significance and pharmacological utility. Reaction of anthranilic acid with benzoyl chloride in pyridine yielded 2-phenyl4H-benzo[d][1,3]oxazin-4-one, which on condensation reaction with the tryptophan in glacial acetic acid afforded 3-(1H-indol-3-yl)-2-(4-oxo-2-phenylquinazolin-3(4H)-yl) propanoic acid (2). Treatmen...

member of the transmembrane G-protein coupled receptors family comprising d , k and m opioid receptors. Its original homology cloning and the isolation from brain extracts of the endogenous ligand, the heptadecapeptide nociceptin (NC), gave rise to a great interest in clarifying its physiological functions. The receptor, distributed in both central and peripheral nervous systems and in non-neur...

quinazolinones are heterocyclic and water insoluble compounds with various pharmacological and biological characteristics (antibacterial, antiswelling, antifungal, parkinson and etc.). they are used for treatment hiv and cancer. this study investigated the effects of 4(3h) quinazlonones-2-ethyl-2-phenyl ethyl (qepe) as a new quinazolinons compounds on the spleen and immunocompetent cells of new...

Millipedes (Diplopoda) are a diverse group of arthropods that include 16 orders represented by approximately 12,000 species in 145 families (Sierwald & Bond, 2007). In 11 of these orders, millipedes are protected from predators by chemical defenses produced in glands that vary in number among orders and are located laterally or mid-dorsally in the diplosegments (Eisner et al., 1978; Hopkin & Re...

We describe a general framework for constructing two-dimensional crystals with prescribed depth and sophisticated three-dimensional features. These crystals may serve as scaffolds for the precise spatial arrangements of functional materials for diverse applications. The crystals are selfassembled from single-stranded DNA components called DNA bricks. We demonstrate the experimental construction...

A series of peptide-based triblock copolymers cons i s t ing of poly(γ -benzy l -L -g lu tamate) -b -po ly (dimethylsiloxane)-b-poly(γ-benzyl-L-glutamate) [PBLG-bPDMS-b-PBLG] were synthesized using ring-opening polymerization (ROP). The chemical structure and degree of polymerizations were evaluated by H NMR. These triblock copolymers form thermoreversible gels in toluene with critical gel conc...

We have identified three novel structures for inhibitors of thepoly(ADP-ribose) polymerase (PARP), a nuclear enzyme activatedby strand breaks in DNA and implicated in DNA repair, apoptosis,organ dysfunction or necrosis. 2-[4-(5-Methyl-1H-imidazol-4-yl)-piperidin-1-yl]-4,5-dihydro-imidazo[4,5,1-i,j]quinolin-6-one(BYK49187), 2-(4-pyridin-2-yl-phenyl)-4,5-dihydro-imidazo[4,...