Suppressor of cytokine signaling (SOCS) proteins are negative feedback regulators of the Janus kinase/signal transducer and activator of transcription (JAK/STAT) pathway. Dysregulation of SOCS protein expression in cancers can be one of the mechanisms that maintain STAT activation, but this mechanism is still poorly understood in oral squamous cell carcinoma (OSCC). Here, we report that SOCS2 p...

Hepatocellular carcinoma (HCC) is one of the leading causes of cancer-related mortality worldwide. MicroRNAs (miRNAs) are important regulators of multiple cellular processes, and the aberrant miRNAs expressions have been observed in different types of cancer including HCC. Their pathysiologic role and their relevance to tumorigenesis are still largely unknown. In this study, we demonstrated the...

The purpose of this study was to investigate whether Typus Melancholicus (TM) personality can be used to explain some individual differences related to the degree of athlete burnout and the features of its process, based on a comparison between TM and non-TM groups. For this purpose, we conducted a questionnaire investigation administered to Japanese university athletes using the Depression-rel...

Sports experts represent a population of people who have acquired expertise in sports training and competition. Recently, the number of studies on sports experts has increased; however, neuroanatomical changes following extensive training are not fully understood. In this study, we used cortical thickness measurement to investigate the brain anatomical characteristics of professional divers wit...

The current diagnosis of overreaching and overtraining is based on exclusion. In the present paper, four possible confirmative tools have been examined in three female speed skaters between 16 and 19 years old. A nonfunctional overreached (NFO) athlete, an athlete who was recovering from NFO and a healthy athlete were examined. The NFO athlete showed high stress and low regeneration levels at t...

the aim of this study was to examine the relationship of coaches’ servant leadership style with team efficacy and male athlete satisfaction in iran handball super league. the research method was descriptive-correlation conducted by standard questionnaires of servant leadership, team efficacy and athlete satisfaction. the population of this study consisted of male players of 12 handball super le...

The purpose of the present study was to investigate the effect of endurance (ET), resistance (RT) and concurrent training (CT) on plasma levels of visfatin, insulin, glucose and insulin resistance of non-athlete men with Obesity. It was a semi-experimental study. Thirty six men [age: 21.48 (0.25), and BF%: 27.39 (0.52)], voluntarily participated in this study after public announcement in univer...

Objective: Endometriosis is a chronic disease that influences approximately 5-15% of women of reproductive age. Some studies have confirmed that numerous microRNAs (miRNAs) are unconventionally expressed in the ectopic endometrium. However, the accurate pathological mechanism of the effect of miRNAs on endometriosis is not completely clear. The aim of this study was to investigate the functiona...