MicroRNAs (miRNAs) are small RNAs that post-transcriptionally regulate gene expression in many multicellular organisms. They are encoded in the genome and transcribed into primary (pri-) miRNAs before two processing steps that ultimately produce the mature miRNA. In order to generate the appropriate amount of a particular miRNA in the correct location at the correct time, proper regulation of m...

BACKGROUND Biological timing mechanisms that integrate cyclical and successive processes are not well understood. C. elegans molting cycles involve rhythmic cellular and animal behaviors linked to the periodic reconstruction of cuticles. Molts are coordinated with successive transitions in the temporal fates of epidermal blast cells, which are programmed by genes in the heterochronic regulatory...

this study was carried out to indicate the effects of olive leaves on arterial blood pressure, blood lipids and growth performance in broiler chickens. experiment was conducted with 5 treatments and 4 replicates with 25 birds per each replicate in a completely randomized design with over all 500 male arian strain 1-day old broilers. the period of study was 42 d. treatments were control, drug of...

the antimicrobial effectiveness of different extracts of chicory (cichorium intybus l.) plant including methanolic, ethylic acetate, chloroformic, and aqueous extracts was evaluated by disk diffusion method. the ethylic acetate extract showed higher antibacterial activity against e. coli compared with others. then, effects of different levels of ethylic acetate extract on growth performance and...

We construct quasiconformal mappings in Euclidean spaces by integration of a discontinuous kernel against doubling measures with suitable decay. The differentials of mappings that arise in this way satisfy an isotropic form of the doubling condition. We prove that this isotropic doubling condition is satisfied by the distance functions of certain fractal sets. Finally, we construct an isotropic...

The authors present the central capacity sharing (CCS) model and derive equations describing its behaviors to explain results from dual-task situations. The predictions of the CCS model are contrasted with those of the central bottleneck model. The CCS model predicts all of the hallmark effects of the psychological refractory period (PRP) pardigm: -1 slope of the PRP effect at short stimulus on...

Stimuli that are clearly positive or negative (hence valence-laden stimuli) have the potential to interrupt unrelated task processing. A typical example is the emotional Stroop effect (ESE) in which responding to a certain task feature (e.g., color) is delayed by the presentation of task-irrelevant valent stimuli (e.g., negative pictures) compared to valence-neutral stimuli. Here we scrutinize ...

Segregation and medicated early weaning are technologies used to optimize the productivity and health of pigs, but these practices may also cause aberrant behaviors indicative of stress. Thus, differences in early- (=10 d of age) and late- (=30 d of age) weaned pigs were investigated. At weaning, pigs were housed in groups of four in 16 pens (eight pens per treatment) in the same facility, and,...

Acute myocardial infarction (AMI) during pregnancy and puerperium is very rare. With a growing number of older women giving birth, AMI may become more common complication of pregnancy. We present a 42-year-old multipara with coagulation disorders in pregnancy who suffered from AMI in the peripartum period, documented by ECG, cardiac markers and echocardiography, with normal coronary arteries on...

During C. elegans development, microRNAs (miRNAs) function as molecular switches that define temporal gene expression and cell lineage patterns in a dosage-dependent manner. It is critical, therefore, that the expression of miRNAs be tightly regulated so that target mRNA expression is properly controlled. The molecular mechanisms that function to optimize or control miRNA levels during developm...