WIM DERAVE,1,2 STEN LUND,3 GEOFFREY D. HOLMAN,4 JØRGEN WOJTASZEWSKI,1 OLUF PEDERSEN,5 AND ERIK A. RICHTER1 1Copenhagen Muscle Research Centre, August Krogh Institute, University of Copenhagen, 2100 Copenhagen; 5Steno Diabetes Center and Hagedorn Research Institute, 2820 Gentofte, Copenhagen; 3Medical Research Laboratory, Aarhus Kommunehospital, 8000 Aarhus, Denmark; 2Department of Movement and ...

Ouellette, Andre J. Mucosal Immunity and Inflammation. IV. Paneth cell antimicrobial peptides and the biology of the mucosal barrier. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G257–G261, 1999.—The hypothesis that epithelial cells release preformed antibiotic peptides as components of mucosal innate immunity has gained experimental support in recent years. In the mammalian small int...

Goodwin, Gary W., and Heinrich Taegtmeyer. Regulation of fatty acid oxidation of the heart by MCD and ACC during contractile stimulation. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E772–E777, 1999.—We tested the hypothesis that the level of malonyl-CoA, as well as the corresponding rate of total fatty acid oxidation of the heart, is regulated by the opposing actions of acetyl-CoA carboxylase ...

Hamdy, Shaheen, David J. Mikulis, Adrian Crawley, Shuwen Xue, Helena Lau, Stanley Henry, and Nicholas E. Diamant. Cortical activation during human volitional swallowing: an event-related fMRI study. Am. J. Physiol. 277 (Gastrointest. Liver Physiol. 40): G219–G225, 1999.—Functional magnetic resonance imaging (fMRI) provides a safe, noninvasive method for studying task-related cortical neuronal a...

NANCY L. GELARDI,1,2 ROBERT E. RAPOZA,1 JOSEPH F. RENZULLI,1 AND RICHARD M. COWETT1,2,3 1Department of Pediatrics, Women & Infants Hospital, Brown University School of Medicine, Providence, Rhode Island 02905-2401; 2Robert Schwartz MD Center for Metabolism and Nutrition, and the Division of Neonatology, MetroHealth Medical Center, Cleveland 44109-1998; and 3Department of Neonatology, The Childr...

Yuan, Pu-Qing, and Hong Yang. Hypothyroidism induces Fos-like immunoreactivity in ventral medullary neurons that synthesize TRH. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E927–E936, 1999.—Altered thyroid statuses are associated with autonomic disorders. Thyrotropin-releasing hormone (TRH) in medullary nuclei regulates vagal efferent activity. Induction of Fos-like immunoreactivity (IR) in me...

In British Columbia, soil rehabilitation aims to restore productivity to forest roads, landings, and trails that are no longer needed for access, and to areas that have suffered unavoidable or accidental damage as a result of forestry operations. Soil rehabilitation is an important component of management strategies to maintain or enhance timber supply in the working forest. Restoring productiv...

Ihlemann, Jacob, Thorkil Ploug, Ylva Hellsten, and Henrik Galbo. Effect of tension on contraction-induced glucose transport in rat skeletal muscle. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E208–E214, 1999.—We questioned the general view that contraction-induced muscle glucose transport only depends on stimulation frequency and not on workload. Incubated soleus muscles were electrically stim...

This study aimed to investigate the effects of polymorphisms of the flavin-containing mono-oxygenase 3 (FMO3) and flavin-containing mono-oxygenase 6 (FMO6) genes on the pharmacokinetics of sulindac sulfide, the active metabolite of sulindac, in patients with preterm labor. Ten single-nucleotide polymorphisms (SNPs) were genotyped, and plasma sulindac sulfide concentrations were measured at 0, 1...

Richey, Joyce M., Marilyn Ader, Donna Moore, and Richard N. Bergman. Angiotensin II induces insulin resistance independent of changes in interstitial insulin. Am. J. Physiol. 277 (Endocrinol. Metab. 40): E920–E926, 1999.—We set out to examine whether angiotensin-driven hypertension can alter insulin action and whether these changes are reflected as changes in interstitial insulin (the signal to...