نتایج جستجو برای: 4 hydroxy 2 nonenal

تعداد نتایج: 3126698  

Journal: :Molecular Nutrition & Food Research 2021

Scope A main risk factor of atherosclerosis is a Western diet (WD) rich in n-6 polyunsaturated fatty acids (PUFAs) sensitive to oxidation. Their oxidation can be initiated by heme iron red meat leading the formation 4-hydroxy-2-nonenal (4-HNE), cytotoxic aldehyde. An increased 4-HNE production implicated endothelial dysfunction and atherosclerosis. By contrast, proanthocyanidins reduces oxidati...

Journal: :American journal of physiology. Heart and circulatory physiology 1999
Philip Eaton Jian-Mei Li David J Hearse Michael J Shattock

4-Hydroxy-2-nonenal (HNE) is a major lipid peroxidation product formed during oxidative stress. Because of its reactivity with nucleophilic compounds, particularly metabolites and proteins containing thiol groups, HNE is cytotoxic. The aim of this study was to assess the extent and time course for the formation of HNE-modified proteins during ischemia and ischemia plus reperfusion in isolated r...

2016
Mason Breitzig Charishma Bhimineni Richard Lockey Narasaiah Kolliputi

20 In this perspective, we summarize and discuss critical advancements in the study of 421 hydroxy-2-nonenal (4-HNE) as it relates to diseases and clinical complications either caused or 22 exacerbated by oxidative stress. Since its identification in 1980, 4-HNE has been extensively 23 studied with an emphasis on its formation, its role in pathology, and its targets. As a reactive 24 aldehyde, ...

Journal: :Investigative ophthalmology & visual science 2009
Jianbin Chen Ling Wang Yan Chen Paul Sternberg Jiyang Cai

PURPOSE 4-Hydroxy-2-nonenal (4-HNE) is a major lipid peroxidation product in the retina and the retinal pigment epithelium. The purpose of the present study was to investigate how NF-E2-related factor-2 (Nrf2) and phosphatidylinositol 3 (PI3K) pathways affect the responses of cultured human retinal pigment epithelial (RPE) cells to 4-HNE. METHODS Cultured ARPE-19 cells were treated with diffe...

Journal: :The Journal of biological chemistry 2008
Larissa M Balogh Arthur G Roberts Laura M Shireman Robert J Greene William M Atkins

4-Hydroxy-2-nonenal (HNE) is a toxic aldehyde generated during lipid peroxidation and has been implicated in a variety of pathological states associated with oxidative stress. Glutathione S-transferase (GST) A4-4 is recognized as one of the predominant enzymes responsible for the metabolism of HNE. However, substrate and product stereoselectivity remain to be fully explored. The results from a ...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 1998
L Tsai P A Szweda O Vinogradova L I Szweda

Aging and the progression of certain degenerative diseases are accompanied by increases in intracellular fluorescent material, termed "lipofuscin" and ceroid, respectively. These pigments are observed within granules composed, in part, of damaged protein and lipid. Modification of various biomolecules by aldehyde products of lipid peroxidation is believed to contribute to lipofuscin and ceroid ...

Journal: :Neuroscience letters 2010
Shuho Tanaka Keiji Tabuchi Tomofumi Hoshino Hidekazu Murashita Shigeki Tsuji Akira Hara

GM-1 ganglioside (GM-1), a glycosphingolipid, is embedded in the lipid layer of neuronal membranes and is one of the neuroprotective agents. To the best of our knowledge, the role of GM-1 has never been examined in hair cell injury. The purpose of this study was therefore to evaluate the effects of GM-1 on acoustic injury of the cochlea. Mice were exposed to 4-kHz pure tone of 128dB SPL (sound ...

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