Ma, Thomas Y., Don Nguyen, Vuong Bui, Hanh Nguyen, and Neil Hoa. Ethanol modulation of intestinal epithelial tight junction barrier. Am. J. Physiol. 276 (Gastrointest. Liver Physiol. 39): G965–G974, 1999.—Previous studies have shown that high concentrations of ethanol ($40%) cause functional damage of the gastrointestinal epithelial barrier by direct cytotoxic effect on the epithelial cells. Th...

The present study was performed to evaluate the in vitro inhibitory potential of sarpogrelate and its active metabolite, M-1, on the activities of nine human cytochrome (CYP) isoforms. Using a cocktail assay, the effects of sarpogrelate on nine CYP isoforms and M-1 were measured by specific marker reactions in human liver microsomes. Sarpogrelate potently and selectively inhibited CYP2D6mediate...

Hellerstein, Marc K., and Richard A. Neese. Mass isotopomer distribution analysis at eight years: theoretical, analytic, and experimental considerations. Am. J. Physiol. 276 (Endocrinol. Metab. 39): E1146–E1170, 1999.—Mass isotopomer distribution analysis (MIDA) is a technique for measuring the synthesis of biological polymers. First developed approximately eight years ago, MIDA has been used f...

We discuss the properties of cosmic ray nuclearites, from the point of view of their search with large nuclear track detector arrays exposed at different altitudes, in particular with the SLIM experiment at the Chacaltaya high altitude lab (5290 m a.s.l.). We present calculations concerning their propagation in the Earth atmosphere and discuss their possible detection with CR39 and Makrofol nuc...

The nematode Caenorhabditis elegans was exposed to natural space radiation using the ESA Biorack facility aboard Spacelab on International Microgravity Laboratory 1, STS-42. For the major experimental objective dormant animals were suspended in buffer or on agar or immobilized next to CR-39 plastic nuclear track detectors to correlate fluence of HZE particles with genetic events. This configu...

Recently, Matiullah et al. described the use of NaOH/ethanol as an etchant for the CR-39 detector, and have determined the corresponding bulk and track etch properties from the track diameter method. In the present work, the bulk and track etch properties of CR39 in NaOH/ethanol were derived from direct measurements. The bulk etch rate has been found to increase with the molarity of NaOH/ ethan...

Solid-state nuclear track detectors, such as CR-39, are widely used in physics and in many inertial confinement fusion (ICF) experiments. In the ICF experiments, the particles of interest, such as D(3)He-protons, have ranges of order of the detector thickness. In this case, the dynamic range of the detector can be extended by recording data on both the front and back sides of the detector. High...

OBJECTIVE To estimate the effect of maternal age on obstetric outcomes. METHODS A prospective database from a multicenter investigation of singletons, the FASTER trial, was studied. Subjects were divided into 3 age groups: 1) less than 35 years, 2) 35-39 years, and 3) 40 years and older. Multivariable logistic regression analysis was used to assess the effect of age on outcomes after adjustin...

Spinal muscular atrophy (SMA), characterized by specific degeneration of spinal motor neurons, is caused by mutations in the survival of motor neuron 1, telomeric (SMN1) gene and subsequent decreased levels of functional SMN. How the deficiency of SMN, a ubiquitously expressed protein, leads to spinal motor neuron-specific degeneration in individuals affected by SMA remains unknown. In this stu...

The pharmacokinetics, metabolism, and excretion of cobimetinib, a MEK inhibitor, were characterized in healthy male subjects (n = 6) following a single 20 mg (200 mCi) oral dose. Unchanged cobimetinib and M16 (glycine conjugate of hydrolyzed cobimetinib) were the major circulating species, accounting for 20.5% and 18.3% of the drug-related material in plasma up to 48 hours postdose, respectivel...