نتایج جستجو برای: 3805 gm2
تعداد نتایج: 775 فیلتر نتایج به سال:
STEM education integrates science, Technology, Engineering, and Mathematics knowledge that is emphasized in Malaysia Education Blueprint 2013-2025. A few elements are drawn Islamic syllabus the lower forms. This study aims to examine extent which absorbed form one three syllabus. Qualitative framework analyses of existence based on perception. Excellent efficient teaching can inculcate students...
Numerical solution of the Helmholtz equation is a challenging computational task, particularly when the wave number is large (high frequency). Recent years have seen great improvements in the finite difference approach to this problem through enhancements of the shifted Laplacian preconditioner, originally introduced in [Bayliss et al., JCP 49:443-457, 1983]. For a recent survey and some new re...
Tay-Sachs and Sandhoff diseases are autosomal recessive neurodegenerative diseases resulting from the inability to catabolize GM2 ganglioside by beta-hexosaminidase A (Hex A) due to mutations of the alpha subunit (Tay-Sachs disease) or beta subunit (Sandhoff disease) of Hex A. Hex B (beta beta homodimer) is also defective in Sandhoff disease. We previously developed mouse models of both disease...
Several lines of transgenic mice with gangliosides GM2/GD2 synthase gene were established, and the expression levels of the transgene in brain, liver, spleen and thymus were analyzed by comparing with those in their litter mates. Among four tissues, brain and skin showed markedly high expression levels of the transgene in Northern blotting. Particularly, transgenic mice skin showed about 10-fol...
We describe a novel immobilization technique to investigate interactions between immobilized gangliosides (GD3, GM1, and GM2) and their respective antibodies, antibody fragments, or binding partners using an optical biosensor. Immobilization was performed by direct injection onto a carboxymethyldextran sensor chip and did not require derivatization of the sensor surface or the ganglioside. The ...
Choleragen and its A protomer catalyzed the hydrolysis of NAD to ADP-ribose and nicotinamide. NADase activity was inhibited by gangliosides GM1 (galactosyl-N-acetylgalactosaminyl-[N-acetylneuraminyl]-galactosylglucosylceramide), GM2 (N-acetylgalactosaminyl-[N-acetylneuraminyl]-galactosylglucosylceramide), GM3 (N-acetylneuraminyl-galactosylglucosylceramide), and GD1a (N-acetylneuraminylgalactosy...
Given polynomials f(x), gi(x), hj(x), we study how to minimize f(x) on the set S = {x ∈ R : h1(x) = · · · = hm1(x) = 0, g1(x) ≥ 0, . . . , gm2(x) ≥ 0} . Let fmin be the minimum of f on S. Suppose S is nonsingular and fmin is achievable on S, which are true generically. This paper proposes a new type semidefinite programming (SDP) relaxation which is the first one for solving this problem exactl...
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