Safe and effective methods for oral bacterial disinfection have been desired, since bacteria cause many infectious diseases such as dental caries, periodontal disease, and endodontic infections. Singlet oxygen ((1)O(2)) is attractive, because it is toxic to prokaryotic cells, but not to eukaryotic cells. We selected irradiation of titanium dioxide (TiO(2)) as a source of (1)O(2), because it has...

BACKGROUND Radiolucent lines and sclerotic margins are often seen on knee radiographs taken a year or longer after knee replacement surgery. Histology has shown that the radiolucent zone is predominantly fibrocartilage and the sclerotic margin is lamellar bone. The reasons for their existence are not clearly understood. METHODS A three-dimensional finite element model of the medial half of th...

BACKGROUND AND PURPOSE There is continuing confusion among practitioners with regard to the optimal choice of anesthetic type for repair of hip fractures. We investigated whether type of anesthetic was associated with short-term mortality after hip fracture surgery. PATIENTS AND METHODS We conducted a retrospective cohort study of patients with surgically treated hip fractures, performed betw...

Initiation of bacterial DNA replication at oriC is mediated by primosomal proteins that act cooperatively to melt an AT-rich region where the replicative helicase is loaded prior to the assembly of the replication fork. In Bacillus subtilis, the dnaD, dnaB and dnaI genes are essential for initiation of DNA replication. We established that their mRNAs are maintained in fast growing asynchronous ...

To the Editor: The prevalence of oseltamivir-resistant influenza viruses A (H1N1) (ORVs) increased dramatically worldwide during the winter of 2007–08 (1). Recent reports indicated that by early 2009 most influenza virus (H1N1) strains were resistant to oseltamivir (2). Resistant viruses were transmitted readily and were as viable and pathogenic as oseltamivir-sensitive viruses (OSVs) (3,4). Th...

BACKGROUND Human milk provides necessary macronutrients (protein, carbohydrate, fat) required for infant nutrition. Lactoferrin (Lf), a multifunctional iron-binding protein predominant in human milk, shares similar protein sequence, structure, and bioactivity with bovine Lf (bLf). This large-scale pediatric nutrition study was designed to evaluate growth and tolerance in healthy infants who rec...

The CGC population is a stabilized composite of 1/2 Red Angus, 1/4 Charolais, and 1/4 Tarentaise germplasm. The objectives of this research were to estimate genetic parameters for weight traits of CGC and to evaluate genetic responses resulting from selection based on the following index: I = 365-d weight 3.2(birth weight). Phenotypes evaluated were birth weight (n = 5,083), 200-d weight (n = 4...