Hepatocellular carcinoma is one of the most common cancers worldwide. During tumorigenesis, tumor suppressor and cancer-related genes are commonly silenced by aberrant DNA methylation in their promoter regions. Zebularine (1-(β-(D)-ribofuranosyl)-1,2-dihydropyrimidin-2-one) acts as an inhibitor of DNA methylation and exhibits chemical stability and minimal cytotoxicity both in vitro and in vivo...

This is a review of the enzymatic mechanism of DNA methyltransferase Dnmt1 and analysis of its implications on regulation of DNA methylation in mammalian cells and design of novel mechanism-based inhibitors. The methylation reaction by Dnmt1 has different phases that depend on DNA substrate and allosteric regulation. Consequently, depending on the phase, the differences in catalytic rates betwe...

Immune-suppressive cell populations, including Tregs and suppressor monocytes, have been implicated in long-term survival of allografts in both human transplant recipients and animal models. The factors that drive differentiation and function of these cell populations are not completely understood. In this issue, Bézie and colleagues identify IL-34 as an important mediator of allograft toleranc...

An N-halamine precursor 2-(3-(6-methyl-4-oxo-1,4-dihydropyrimidin-2-yl)ureido)ethyl methacrylate (SCMHBMA) was synthesized and grafted on cotton fabrics via atom transfer radical polymerization for antibacterial function after chlorination. The preparation chlorinated (Cotton-g-PSMA-Cl) were characterized with FTIR, XPS, SEM, TGA. properties of prepared Cotton-g-PSMA-Cl, including thermal prope...

In this work, preparation and crystallization of yttrium iron garnet Y3Fe5O12 super-paramagnetic nanoparticle by aqueous sol–gel processes and its application as an effective nano catalyst for esterification and etherification reactions in short reaction time and in high isolated yields. Then this catalist was used for the synthesis of Dihydropyrimidin derivatives is described. The catalyst was...

Methods Design: retrospective pre-post study. Protocol: in our database we searched for all patients who were prescribed a Sibilla, or Sforzesco Brace, 21h per day or more for AIS, 30-35° Cobb, more than 10 years old at first evaluation, and no previous brace treatment. We compared data from the last visit before beginning the brace, and the first visit after 6 months of brace treatment. Sforze...

nanostructured ruo2 powders were synthesized via a hydrothermal method at 180 °c for 12 h using 1 and 2 m naoh aqueous solutions. the structure of the obtained nanomaterials was investigated by powder x-ray diffraction (pxrd) technique. the morphology the obtained materials were studied by field emission scanning electron microscope (fesem). the technique showed that with changing the reaction ...