The lipid-lowering activity of a series of novel N-(benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide derivatives has been studied in Triton WR-1339-induced hyperlipidemia in rats. The test animals were divided into four groups: control, hyperlipidemic, compound + 4% DMSO [C1: N-(2-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (1), C2: N-(3-benzoylphenyl)-5-fluoro-1H-indole-2-carboxamide (2), C...

there has been special interest in the chemistry of quinolone and pyrimidine derivatives due to their diverse biological activities such as anticonvulsant, anti-malarial agents, antibacterial, antiviral, cytostatic, antithelemintic, antigenotoxic, anti-cancer agents. these compounds are also used as targeting delayed-type hypersensivity and anti-convulsant agents. as a part of our research work...

Corrosion inhibition of Cu10Ni alloy in 0.5 M HCl solution using acrylonitrile derivatives namely: (E)-2(1H-indole-3-carbonyl)-3-(2-oxo-2-phenylethylthio)-3-(phenylamino)acrylonitrile(a),(E)-2-(1H-indole-3carbonyl)-3-mercapto-3-(phenylamino)acrylonitrile(b)and(Z)-2-(1H-indole-3-carbonyl)-3 phenylacrylonitrile (c) was investigated by potentiodynamic polarization, electrochemical impedance spectr...

In this communication, we introduce squaric acid derivatives as anhydrous proton conductors. We report the synthesis, characterization and proton conductivities of four squaric acid derivatives. The anhydrous proton conductivity of one of the derivatives was 2.3 × 10(-3) S cm(-1) at 110 °C, comparable to the conductivity of molten 1H-1,2,3-triazole or 1H-imidazole.

(4-(Adamantan-1-yl)-1-(isopropyl)-1H-imidazol-2-yl)methanol was prepared through a five-step process starting from commercially available 1-acetyladamantane. Each step proceeded in moderate-to-excellent yields and the overall yield across five steps 28%. The compound identified characterized by 1H 13C{1H} NMR, high-resolution mass spectroscopy, elemental analysis. This its derivatives have pote...