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CONTEXT Genome-wide association studies (GWAS) have recently identified CLU, PICALM, and CR1 as novel genes for late-onset Alzheimer disease (AD). OBJECTIVES To identify and strengthen additional loci associated with AD and confirm these in an independent sample and to examine the contribution of recently identified genes to AD risk prediction in a 3-stage analysis of new and previously publi...
در تحقیق و مطالعه مباحث آیرودینامیکی، تونل باد از اهمیت زیادی برخوردار است. تونل باد جریان هوای کنترل شده ای را ایجاد می کند که از اطراف مدل مورد نظر عبور کرده و بدین ترتیب اطلاعات لازم از چگونگی عبور جریان هوا از اطراف مدل به دست می آید. کیفیت جریان هوای داخل تونل باد با میزان یکنواختی، اندازه شدت اغتشاش ها و زاویه جریان آن مشخص می شود. تونل باد باید بگونه ای باشد که جریان هوای یکنواخت با حداق...
BACKGROUND Adenoidectomy is one of the most common surgical procedures performed in children in the United States. Indications for adenoidectomy include chronic or recurrent otitis media, as well as subjective upper airway obstructive symptoms such as nasal obstruction with chronic mouth breathing, snoring, chronic rhinitis, and chronic or recurrent sinusitis. When the indication includes obstr...
This study describes the main treatment effects of organic matter removal and compaction and a split-plot effect of competition control on mineral soil carbon (C) and nitrogen (N) pools. Treatment effects on soil C and N pools are discussed for 19 sites across five locations (British Columbia, Northern Rocky Mountains, Pacific Southwest, and Atlantic and Gulf coasts) that are part of the Long-T...
In t ramembranous charge movement was measured in cut twitch fibers mounted in a double Vaseline-gap chamber with ei ther a tetraethylammonium chloride (TEA.CI) o r a TEA2.SO 4 solution (13-14~ in the central pool. Charge vs. voltage data were fitted by a single two-state Boltzmann distr ibution function. The average values of V (the voltage at which steady-state charge is equally distr ibuted ...
Refeeding is the first step in long-term nutritional rehabilitation of patients with anorexia nervosa (AN). It may begin in the outpatient setting or in the hospital, if close medical and/or psychiatric monitoring is needed. In either case, early weight gain appears to be crucial for recovery. In hospital, faster weight gain [1] and higher weight upon discharge [2, 3] predict weight recovery at...
Acetate Transport in the $3 Segment of the Rabbit Proximal Tubule and its Effect on Intracellular pH
We moni to red intracellular p H (pH.~ in isolated perfused $3 segments o f the rabbi t proximal tubule, and s tudied the effect o f acetate (Ac-) transpor t on p H i. p h i was calculated from the absorbance spect rum of 4' ,5'-dimethyl5-(and 6) carboxyfluorescein t r apped intracellularly. All solutions were nominally HCO~-free. Removal o f 10 mM Acf rom bath and lumen caused pH~ to rapidly r...
Infiltration and extravasation are risks of intravenous administration therapy involving unintended leakage of solution into the surrounding tissue. Consequences range from local irritation to amputation. While immediate action using appropriate measures (ie, dilution, extraction, antidotes, and supportive treatments) can decrease the need for surgical intervention, many injuries may be prevent...
BACKGROUND After the fall of the Taliban in 2001, Afghanistan experienced a tumultuous period of democracy overshadowed by conflict, widespread insurgency, and an inflow of development assistance. Although there have been several cross-sectional assessments of health gains over the last decade, there has been no systematic analysis of progress and factors influencing maternal and child health i...
We used the absorbance spectrum of 4',5'-dimethyl-5-(and 6) carboxyfluorescein to measure intracellular pH (pHi) in the isolated, perfused $3 segment of the rabbit proximal tubule. Experiments were conducted in HCO~-free solutions, pH~ recovered from an acid load imposed by an NH~ prepulse, indicating the presence of one or more active acid-extrusion mechanisms. Removal of Na + from bath and lu...
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