Malignant rhabdoid tumor (MRT), a highly aggressive cancer of young children, displays inactivation or loss of the hSNF5/INI1/SMARCB1 gene, a core subunit of the SWI/SNF chromatin-remodeling complex, in primary tumors and cell lines. We have previously reported that reexpression of hSNF5 in someMRT cell lines causes a G1 arrest via p21 (p21) mRNA induction in a p53-independent manner. However, ...

IMPORTANCE There is a need for more effective pharmacotherapy for chronic pain, including pain in inherited erythromelalgia (IEM) in which gain-of-function mutations of sodium channel NaV1.7 make dorsal root ganglion (DRG) neurons hyperexcitable. OBJECTIVE To determine whether pain in IEM can be attenuated via pharmacotherapy guided by genomic analysis and functional profiling. DESIGN, SETT...

Academics have a public duty to use their research to promote improvements in patient care and health. Here, we argue that there is an imperative to translate recent compelling evidence demonstrating the importance of the periconceptional period in determining the health of future generations, into improvements in pregnancy-related care and perinatal health. Taking this action has the potential...

Both the practice and indications for dobutamine stress echocardiography (DSE) have changed over the past 15 years. At first DSE was the prerogative of a few enthusiastic cardiologists working at specialized centres, but this technique has developed into a commonly used practical tool with widespread availability. In the early years DSE was used for the assessment of coronary artery disease; te...

As noted repeatedly, the treatment of in-stent restenosis remains one of the most vexing shortcomings in interventional cardiology. Coronary restenosis is often manifested by symptom recurrence, which is translated into an increased rate of repeat revascularization. In this issue, Radke and colleagues report the results of a well-conducted meta-analysis with data gathered from published reports...

The Early vs. Late Infantile Strabismus Surgery Study Group is a group of strabismologists and orthoptists who investigate whether early or late surgery is preferable in infantile strabismus, in a non-randomized, prospective, multi-centre trial. Infants between 6 and 18 months of age will receive a standardized entry examination and then be operated either before their second anniversary in cli...

Nuclear etic resoaace (NMR) relaxation times were studied in acclhnated and nonacclmated Kharkov winter wheat (Tritlum sestlvwm L.) crowns and acclimated cel aggregates to determine if membrane permeability was altered by freezing. The NMR water signal decay consisted of two exponental c ets: a short one arising from extracellular water, and a long one arising from intracelular water. A slow fr...

Normal and tumoral pituitary corticotropic cells express sst 2 and sst 5 , of which sst 5 is the predominantly expressed receptor subtype. Somatostatin (SS) inhibits pituitary adrenocorticotropin hormone (ACTH) secretion in vitro, but the sensitivity to SS is strongly regulated by glucocorticoids. In pathological conditions of a low endogenous cortisol level, i.e. in patients with adrenal insuf...

A 58-year-old male patient underwent aortic valve replacement surgery (On-X mechanical prosthesis, ring size 23 mm) due to severe aortic valve stenosis with preserved LV function and normal coronary arteries. The postoperative period was complicated by third-degree AV block and sustained ventricular tachycardias and a DDD-ICD implantation was implanted. After 3 months of surgery, the patient pr...

Tumor cells prepared from PRL-secreting rat pituitacy 73 156 tumors qf increa.ting weight were separated on continuous Percoll density gradients, according to d$jerences in their density. Whether the cell subpopulations obtained E$ dens& gradient separation .\hou,ed differences in protein content per cell, PRL production per cell, groutth rates and respon.kenej.c to the somatostatin analog SMS ...