There are some reports which indicate that several triazole derivatives have inotropic activity; however, the cellular site and mechanism of action at cardiovascular level is very confusing. In order, to have a clear understanding of these phenomena, a triazole derivative was synthesized to evaluate its biological activity on left ventricular pressure and characterize the molecular mechanism. T...

ABSTRACT. Inclusion complex between 3-amino-1,2,4-triazole picrate and β-cyclodextrin was synthesized in order to increase the solubility. The obtained by co-precipitation method its stoichiometry is 1:1 (guest–host). structure of has been established UV, X-ray diffractometry powder spectra, TGA, DSC, IR, 1H NMR, 13C NMR. influence effect pH on complexation discussed. value apparent formation c...

a series of 3-alkoxy-4-(4-(hexyloxy/heptyloxy) phenyl)-4h-1,2,4-triazole was synthesized. the anticonvulsant effect and neurotoxicity of the compounds were calculated with maximal electroshock (mes) test and rotarod tests with intraperitoneally injected mice. among the synthesized compounds, compound 3-heptyloxy-4-(4-(hexyloxy) phenyl)-4h-1,2,4-triazole (5f) was the most active one and also had...

to improve the corrosion protection of copper metal, 0.01m concentration of 1h-1,2,4-triazole-3-thiol (tat) was incorporated into the hybrid sol-gel monolayers containing 3-glycidoxypropyltrimethoxysilane (gptms) and tetraethoxysilane (teos). it was further subjected to hydrolysis and condensation reaction to form a sol-gel matrix. the tat-doped hybrid sol-gel coating was applied over the coppe...

Tert-butyl carbazate (1) reacted with ammonium thiocyanate and phenyl isothiocyanate to afford the corresponding 5-tert-butoxy-4H-1, 2, 4-triazole-3-thiol (3) 5-tert-butoxy-4-phenyl-2H1, 2, 4-triazole-3(4H)-thione 5 respectively. Compound (1) also reacted with carbon disulfide and potassium hydroxide to afford 5-tert-butoxy-1, 3, 4-oxadiazole-2(3H)-thione 6. Treatment of 6 with methyl iodide, 2...

The asymmetric unit of the title hydrated salt, (C10H18N8S2)2[BiCl6]NO3·2H2O, contains two independent 3-amino-1-carbamo-thioyl-5-[(2-{[(5-methyl-1H-imidazol-3-ium-4-yl)meth-yl]sulfan-yl}eth-yl)amino]-1H-1,2,4-triazol-4-ium cations, one hexa-chloridobismuthate anion, one nitrate anion and two solvent water mol-ecules. The dihedral angles between the imidazole and triazole rings in the cations a...

Triazoles are an important class of compounds used as core molecule for the synthesis of many pharmaceutical drugs. The objective of the present research was to investigate the influence of biofield treatment on physical, spectral and thermal properties of 1,2,4-triazole. The study was performed in two groups, control and treatment. The control group remained as untreated, and biofield treatmen...