Journal of Lipid Research Volume 52, 2011 245 Copyright © 2011 by the American Society for Biochemistry and Molecular Biology, Inc. Essential fatty acids, i.e., linoleic (C18:2n-6) and -linolenic acid (C18:3n-3), which are prerequisites for normal growth, development, and function in mammals, cannot be synthesized de novo and, as such, have to be derived from diet ( 1 ). Subsequently, the C18:2...

Abstract Objectives Omega-3 (n-3) polyunsaturated fatty acids (PUFAs) are essential in fetal growth and development have been shown to modulate inflammatory processes throughout the lifespan. Previous studies demonstrated that individuals with lower socioeconomic status (SES) may be at risk for low intake of n-3 PUFAs, however, no research has compared concentrations these nutrients present mat...

Fish and shellfish are widely available foods that provide important nutrients, particularly n-3 polyunsaturated fatty acids (n-3 PUFAs), to many populations globally. These nutrients, especially docosahexaenoic acid, confer benefits to brain and visual system development in infants and reduce risks of certain forms of heart disease in adults. However, fish and shellfish can also be a major sou...

A growing body of clinical and epidemiological evidence suggests that low dietary intake and/or tissue levels of n-3 (omega-3) polyunsaturated fatty acids (PUFAs) are associated with postpartum depression. Low tissue levels of n-3 PUFAs, particularly docosahexaenoic acid (DHA), are reported in patients with either postpartum or nonpuerperal depression. Moreover, the physiological demands of pre...

Long-chain n-3 polyunsaturated fatty acids (PUFAs) can derive from diet or from α-linolenic acid (ALA) by elongation and desaturation. We investigated the association of common genetic variation with plasma phospholipid levels of the four major n-3 PUFAs by performing genome-wide association studies in five population-based cohorts comprising 8,866 subjects of European ancestry. Minor alleles o...

BACKGROUND Based on animal studies, n-3 polyunsaturated fatty acids (PUFAs) have been suggested to lower the risk of obesity and inflammation. We aimed to investigate if, among humans, intake of n-3 PUFAs was associated with i) total body fat, ii) body fat distribution and iii) obesity-related inflammatory markers. METHODS The study population consisted of 1,212 healthy individuals with infor...

Aim. To evaluate the literature data on efficacy of omega-3 polyunsaturated fatty acids (PUFAs) in prevention postoperative atrial fibrillation (POAF) elective cardiac surgery, including onor off-pump coronary artery bypass grafting and/or valve replacement repair. Material and methods. The search for studies was carried out using PubMed database Google Scholar from 2005 to January 31, 2022. Fr...

Breast cancer represents one of the most common forms of cancer in women worldwide, with an increase in the number of newly diagnosed patients in the last decade. The role of fatty acids, particularly of a diet rich in ω-3 and ω-6 polyunsaturated fatty acids (PUFAs), in breast cancer development is not fully understood and remains controversial due to their complex mechanism of action. However,...

INTRODUCTION Over the last 40 years omega-3 polyunsaturated fatty acids (PUFAs) have been shown to be anti-arrhythmic or pro-arrhythmic depending on the method and duration of administration and model studied. We previously reported that omega-3 PUFAs do not confer anti-arrhythmic properties and are pro-arrhythmic in canine model of sudden cardiac death (SCD). Here, we evaluated the effects of ...