The title compound, C(14)H(10)F(3)NO(3), was prepared by a palladium-catalysed Suzuki-Miyaura coupling reaction. The dihedral angle between the nitro group and its parent benzene ring is 66.85 (19)° while the dihedral angle between the two benzene rings is 49.98 (9)°. The CF(3) group is disordered over two sets of sites with occupancies of 0.457 (8) and 0.543 (8).

Organic extracts of six urine samples from children treated with nitisinone, a medicine against tyrosinemia type I, were investigated by (1)H and (19)F NMR spectroscopy. The presence of unchanged 2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione (NTBC), 6-hydroxy-2-[2-nitro-4-(trifluoromethyl)benzoyl]cyclohexane-1,3-dione (NTBC-OH) and 2-nitro-4-trifluoromethylbenzoic acid (NTFA) as w...

a series of ortho -hydroxypyridine-4-ones were prepared in high yields and evaluated for antioxidant and iron chelating activities. n 1 -h hydroxypyridinones va , vb , and ve were the best radical scavengers in dpph free radical scavenging assay. compound vb was proved to be the most potent compound in hydrogen peroxide scavenging assay. all of the synthesized compounds had very close chelating...

a series of five-membered heterocyclic rings were synthesized by the reaction between benzoyl chloride and various chlolro-nitro-benzoyl chlorides and semi carbazide to form (c1-c7) compounds and was tested for their anti-inflammatory activity determined by rat-paw-oedema method. all the synthesis compounds have been characterized by 1hnmr, ir and mass spectral data. the compounds were purified...

A series of two-way diode array chromatograms were recorded at 0.1±0.5% and 1±5% of 3-hydroxypyridine impurity coeluting with 2-hydroxypyridine, recorded at pH 4.9 (good resolution) and 5.0 (poor resolution). Four methods for PLS calibration, namely, using summed spectral pro®les, summed elution pro®les, unfolded three-way PLS and true three-way PLS were applied to the datasets, both using auto...

3 Starting from 2-methyl-4-nitro-imidazole, new 5-(2-methyl- 4-nitro-1-imidazomethyl)-1,3,4-oxadiazole-2-thione () was synthesized and was subjected to Mannich reaction with appropriate amines to yield a new series of 3-substituted aminomethyl-5-(2-methyl-4-nitro-1-imidazomethyl)- 1,3,4-oxadiazole-2-thiones (4a-j). The structure of the title compounds was elucidated by elemental analysis and sp...

The metabolism of 3-hydroxyp)ridine, a significant constituent of tobacco smoke, to 2,5-dihydroxypyridine has been characterized in he patic microsomes and in the reconstituted enzyme system using purified forms of P450. The redox cycling activity of the metabolite and its ability to damage DNA in vitro have been examined. Pyridine-induced microsomes, which contain elevated levels of P4SOIIE1 (...