Previous studies have shown that telomeric P elements inserted at the left end of the X chromosome are anchors of the P cytotype, the maternally inherited state that regulates P-element activity in the germ line of Drosophila melanogaster. This regulation is mediated by small RNAs that associate with the Piwi family of proteins (piRNAs). We extend the analysis of cytotype regulation by studying...

The thermomechanical behavior of damaged space shuttle tile thermal protection system is determined using the finite element method. The relative effects of damage on the thermal protection capability and the induced thermal stresses in the TPS are determined by comparing the thermal and structural response of the damaged configurations with the undamaged configurations. The TPS, consisting of ...

Precut papillotomy (PP) is a useful technique for overcoming a difficult biliary cannulation (DBC). Various techniques and devices have been introduced for successful PP. PP using needle-knife (NK) is the main modalities, and PP using pull-type papillotome, transpancreatic septotomy (TPS), was firstly introduced by Goff in 1995. After then TPS with or without guidewire or/and pancreatic stent w...

Given an undirected graph with costs associated with each edge as well as each pair of edges, the quadratic minimum spanning tree problem (QMSTP) consists of determining a spanning tree of minimum cost. QMSTP is useful to model many reallife network design applications. We propose a three-phase search approach named TPS for solving QMSTP, which organizes the search process into three distinctiv...

AIMS We tested the hypothesis that dyssynchrony of left ventricular (LV) myocardial deformation evaluated by ultrasound can predict success of cardiac resynchronization therapy (CRT) in patients with heart failure (HF). METHODS AND RESULTS Thirty-seven patients with dilated cardiomyopathy, New York Heart Association class III-IV, LV ejection fraction (EF) < or =35%, QRS > 120 ms were studied ...

UNLABELLED Abstract Objective: To assess the impact of nonuniform dose distribution within lesions and tumor-involved organs of patients receiving Zevalin(®), and to discuss possible implications of equivalent uniform biological effective doses (EU-BED) on treatment efficacy and toxicity. MATLAB™ -based software for voxel-based dosimetry was adopted for this purpose. METHODS Eleven lesions fr...

ᅟ: Accurate and quantitative dosimetry for internal radiation therapy can be especially challenging, given the heterogeneity of patient anatomy, tumor anatomy, and source deposition. Internal radiotherapy sources such as nanoparticles and monoclonal antibodies require high resolution imaging to accurately model the heterogeneous distribution of these sources in the tumor. The resolution of nucl...

Pesticides generate transformation products (TPs) when they are released into the environment. These TPs may be of ecotoxicological importance. Past studies have demonstrated how difficult it is to predict the occurrence of pesticide TPs and their environmental risk. The monitoring approaches mostly used in current regulatory frameworks target only known ecotoxicologically relevant TPs. Here, w...

Telocytes (TCs), a new type of interstitial cells, were identified in many different organs and tissues of mammalians and humans. In this study, we show the presence, in human oesophagus, of cells having the typical features of TCs in lamina propria of the mucosa, as well as in muscular layers. We used transmission electron microscopy (TEM), immunohistochemistry (IHC) and primary cell culture. ...