We have shown that a multicompartment model accurately predicts end-tidal (ET) sevoflurane (sevo) and isoflurane concentrations. The model has been adapted to use real-time fresh gas flow and vaporizer settings to display a 10-min prediction of ET sevo concentrations. In this study, we evaluated the effect of the predictive display on the speed and accuracy of changes in ET sevo by the anesthes...

The rate of unidirectional [14C]urea efflux from human red cells was determined in the self-exchange and net efflux modes with the continuous flow tube method. Self-exchange flux was saturable and followed simple Michaelis-Menten kinetics. At 38 degrees C the maximal self-exchange flux was 1.3 X 10(-7) mol cm-2 s-1, and the urea concentration for half-maximal flux, K1/2, was 396 mM. At 25 degre...

The complexation of urea (U) with manganese(II), cobalt(II), iron(III) and copper(II) ions at different temperatures has been studied by many methods namely elemnental analysis, magnetic susceptibility, conductivity measurements, infrared and thermal analysis (TG/DTG), scanning electron microscopy (SEM), Energy-dispersive X-ray spectroscopy (EDX), and x-ray powder diffraction (XRD). The high va...

KLEINMAN, LEONARD I., EDWARD P. RADFORD, JR., AND GIORGIO TORELLI. Urea and inulin clearances in undisturbed, unanesthetized rats. Am. J. Physiol. 208(3) : 578-584. 1g65.Inulin and urea clearances were determined simultaneously on unanesthetized, undisturbed rats with catheters permanently inserted in the abdominal aorta, jugular vein, and urinary bladder. The rats were fed a) a normal Purina c...

Urea is the principal end-product of nitrogen metabolism in mammals and is excreted almost entirely through the kidney. Studies by Shannon (1, 2) in the dog and by Chasis and Smith (3, 4) in man have shown that the renal clearance of urea is less than the inulin or creatinine clearance at all rates of urine flow, and that the clearance of urea increases as the urine flow rises. These observatio...

We have developed a modular scaffold for preparing high-affinity, homo-multivalent inhibitors of the prostate-specific membrane antigen (PSMA) for imaging and therapy of prostate cancer (PCa). Our system contains a lysine-based (µ-, e-) dialkyne residue for incorporating a PSMA binding Lys-Glu urea motif exploiting click chemistry and a second lysine residue for subsequent modification with an ...

1. In rats deprived of food and water for 24 h acute renal failure was produced by the intramuscular injection of glycerol. Eight hours later plasma urea concentration had increased threefold despite a small rise in urine volume. Plasma concentrations of renin and renin substrate were elevated. 2. When saralasin, a competitive antagonist of angiotensin II, was infused for 8 h after glycerol inj...

Toxocariasis is a zoonotic disease in that IgM titers can remain high for long periods making difficult to determine the stage of the disease. The aim of this study is to investigate the applicability of indirect ELISA, associated with urea, to discriminate between the acute and chronic toxocariasis. IgG avidity was evaluated in 25 BALB/c mice experimentally infected with 1000 Toxocara canis eg...