Demanding that charged Nariai black holes in (quasi-)de Sitter space decay without becoming super-extremal implies a lower bound on the masses of particles, known as Festina Lente (FL) bound. In this paper we fix $\mathcal{O}(1)$ constant and elucidate various aspects it, well extensions to $d>4$ situations with scalar potentials dilatonic couplings. We also discuss phenomenological implication...

The introduction of rituximab (R) has measurably improved the outcome of patients with follicular lymphoma (FL) and diffuse large B-cell lymphoma (DLBCL). To evaluate the outcome of patients with FL and DLBCL under R plus CHOP therapy, we performed a retrospective analysis in Yokohama City University Hematology Group in Japan. Five hundred and twenty-six patients (158, FL ; 368, DLBCL) were sch...

Follicular lymphoma (FL) is the second most common non-Hodgkin lymphoma in the Western world. FL cell-intrinsic and cell-extrinsic factors influence FL biology and clinical outcome. To further our understanding of the genetic basis of FL, we performed whole-exome sequencing of 23 highly purified FL cases and 1 transformed FL case and expanded findings to a combined total of 114 FLs. We report r...

OBJECTIVE The exon 3-deleted/full-length (d3/fl) growth hormone receptor (d3/fl-GHR) polymorphism has been associated with responsiveness to GH therapy in some children and also with adult height variation in the general population. We aimed to evaluate the distribution of d3/fl-GHR polymorphism in a Turkish population. METHODS The study included 477 (54 females/423 males) healthy adults with...

OBJECTIVES This study was directed at developing spatial 62-lead electrocardiogram (ECG) criteria for classification of counterclockwise (CCW) and clockwise (CW) typical atrial flutter (Fl) in patients with and without structural heart disease. BACKGROUND Electrocardiographic classification of CCW and CW typical atrial Fl is frequently hampered by inaccurate and inconclusive scalar waveform a...

Let C (fl), fl > 0, denote the family of no rmal i zed c loseto-convex funct ions of o rder ft. F o r fl = 1 this is the usual set of c loseto-convex functions, which had been defined by Kap lan . In a prev ious pape r [3] we solved the Fekete-Szeg6 p r o b l e m of maximiz ing l a 3 2 a2l, 2 ~ [0, 1], for c loseto-convex functions. The largest n u m b e r 20 for which [a a 20 a2[ is max imized...

Th is article examines the joint impact of three types of operational fl exibility in a theoretical model of a two-product fi rm that makes capacity, production and pricing decisions at three points in time with an underlying continuous-time information evolution. Mix fl exibility is measured by the cost of switching production between the two products. Volume fl exibility is measured by the fr...

Flt3 ligand (FL) has been proposed as a possible modulator hanced or depleted the number of precommitted cells in expansion culture, CD34 CD38 and HLA-DR fractions of early hematopoietic cell growth. The purpose of this study was to analyze the impact of FL on ex vivo expansion of were incubated in liquid culture and analyzed by flow cytometry. Inclusion of FL enhanced the absolute number of pr...

In three lymphoma cell lines carrying t(14;18), named FL-18, FL-218, and FL-318, the genomic organization of IgH gene was compared with the expression of bcl-2 gene; the t(14;18) of the FL-18 cells occurred downstream from the major breakpoint cluster region (mbr) of a bcl-2 gene, and that of the FL-218 and FL-318 cells within the mbr. The FL-318 expressed the normal-sized bcl-2 transcript of 8...

BACKGROUND 2'-Fucosyllactose (2-FL) is a functional oligosaccharide present in human milk which protects against the infection of enteric pathogens. Because 2-FL can be synthesized through the enzymatic fucosylation of lactose with guanosine 5'-diphosphate (GDP)-l-fucose by α-1,2-fucosyltransferase (FucT2), an 2-FL producing Escherichia coli can be constructed through overexpressing genes codin...