A method for the analysis of six taste and odour causing compounds in aqueous samples using the granular adsorbent, Ambersorb 572, and gas chromatography-high resolution mass spectrometry (GC-HRMS) has been developed. This method for the determination of geosmin, 2-methylisoborneol (2-MIB), 2-isopropyl-3-methoxypyrazine (IPMP), 2-isobutyl-3-methoxypyrazine (IBMP), 2,3,6-trichloroanisole (236-TC...

PRAS40 binds to the mTORC1 (mammalian target of rapamycin complex 1) and is released in response to insulin. It has been suggested that this effect is due to 14-3-3 binding and leads to activation of mTORC1 signalling. In a similar manner to insulin, phorbol esters also activate mTORC1 signalling, in this case via PKC (protein kinase C) and ERK (extracellular-signal-regulated kinase). However, ...

Chorismate mutase acts at the first branchpoint of aromatic amino acid biosynthesis and catalyzes the conversion of chorismate to prephenate. Comparison of the x-ray structures of allosteric chorismate mutase from the yeast Saccharomyces cerevisiae with Escherichia coli chorismate mutase/prephenate dehydratase suggested conserved active sites between both enzymes. We have replaced all critical ...

PURPOSE A diverting stoma is known to reduce the consequences of distal anastomotic failure following colorectal surgery. The aim of this study was to evaluate the efficacy of a diverting stoma after an ultra-low anterior resection (uLAR) for rectal cancer. METHODS Between 2000 and 2007, 836 patients who underwent an uLAR were divided into two groups, depending on the fecal diversion: 246 rec...

In some nuclear models, neutron magic numbers intersect the neutron drip line for nuclei having about 123, 187 and 264 nucleons. These masses corresponds, in GeV, to 115, 175 and 246. Reversing the argument, it can be said that a study of the neutron drip line predicts the existence of three physical scales at 115 GeV, 175 Gev and 246 Gev. Figure 1: figure 10 of [3], plus an inset of figure 20....

Amebiasis is a protozoan disease caused by Entamoeba histolytica and a potential health threat in areas where sanitation and hygiene are inappropriate. Highly sensitive PCR methods for detection of E. histolytica in clinical and environmental samples are extremely useful to control amebiasis and to promote public health. The present study compared several primer sets for small subunit (SSU) rDN...

BACKGROUND Lynch Syndrome (LS) is the most common cause of inherited colorectal cancer (CRC). In British Columbia, most centres still use clinical criteria (Amsterdam II, Revised Bethesda, or the BC Cancer Agency's criteria) to determine who should undergo further first-line testing in the form of microsatellite instability or immunohistochemistry staining. Given the limitations with this strat...

s / Porto Biomed. J. 2017;2(5):176–246 199 Acknowledgements: This work was supported by the Portuguese Group of Studies in Inflammatory Bowel Disease (GEDII). http://dx.doi.org/10.1016/j.pbj.2017.07.055

This is a corrigendum to the article 'Inhibition of Key Digestive Enzymes Related to Diabetes and Hyperlipidemia and Protection of Liver-Kidney Functions by Trigonelline in Diabetic Rats' [Sci Pharm. 2013; 81: 233–246]. Figure 6 is replaced.

Mutations in the TP53 tumor suppressor gene occur at different frequencies in a variety of human malignancies. TP53 encodes a DNA-binding transcription factor that induces cell growth arrest, senescence and cell death by apoptosis upon cellular stress, including oncogenic stress and DNA damage. In hematological malignancies TP53 mutations are common in relapsed/refractory disease and confers a ...