Dose-dependent pharmacokinetic of phenytoin necessitates the estimation of the maximum rate of metabolism (Vm) and the Michaelis-Menten constant (Km) in a concerned population. The aim of this study was to determine the pharmacokinetic parameters of phenytoin in a sample of Iranian patients to optimize the antiepileptic pharmacotherapy. Fourty patients who received a constant dose of phenytoin ...

[1] Isotropic and anisotropic seismic structures across the Northern Apennines (Italy) subduction zone are imaged using a new method for the analysis of teleseismic receiver functions (RFs). More than 13,000 P‐wave coda of teleseismic records from the 2003–2007 Retreating‐Trench, Extension, and Accretion Tectonics (RETREAT) experiment are used to provide new insights into a peculiar subduction ...

In Summer 1998, a 400 km long seismic refraction profile (INDEPTH III) was shot in Central Tibet. Apart from recording the signals of 11 shots along the line, the stations also recorded a number of local earthquakes more or less in the extension of the line. Record sections and travel time data from both shots and earthquakes were compiled and interpreted jointly. The following peculiarities ar...

iran is located in an area with high earthquake risk. there are over 20 active faults with length of 500 km and also densely populated parts of the country have been rendered vulnerable to strong earthquakes. however, existence of eight faults of the main faults of iran along with at least 18 faults with length of more than 100 km in kerman province have turned the place into one of the riskies...

Abstract The crust beneath transform faults at slow-spreading ridges has been considered to be thin, comprising a thin mafic layer overlying serpentinized peridotite. Using wide-angle seismic data, we report the presence of Moho ?6 km depth and low-velocity anomaly extending down 9 20-km-wide Romanche valley floor in equatorial Atlantic Ocean. low crustal velocities above could due either highl...

[1] The Talkeetna arc is one of two intraoceanic arcs where much of the section from the upper mantle through the volcanic carapace is well exposed. We reconstruct the vertical section of the Talkeetna arc by determining the (re)crystallization pressures at various structural levels. The thermobarometry shows that the tonalites and quartz diorites intruded at 5–9 km into a volcanic section esti...

Identifying suitable models for estimating soil erosion is one of the most importantissues facing decision makers and managers in comprehensive planning and management ofsoil and water. In this research, with the purpose of estimating soil erosion in LorestanProvince, the conventional SLEMSA method was jointly used with OWA (orderedweighted avera...

The INFN NEMO-OνDE (Ocean Noise Detection Experiment) station, deployed on the seafloor at 2000 m depth 25 km offshore Catania (Sicily, Italy) in year 2005, was designed to continuously transmit broad-band acoustic data through optical cables to the INFN lab located in the port of Catania. It was operational until November 2006, when it was replaced by other experimental equipment. During the o...

Re-valuated instrumental magnitudes and intensity distributions for the Mw8.0 Shillong Plateau earthquake of 1897 and the Mw7.8 Kangra earthquake of 1905, combined with newly available geodetic constraints on rupture geometries, allow us to compare observed distributions of intensity with those predicted from theoretical models for shaking produced by each earthquake. The difference between pre...