Compound 1 [(E)-4-fluoro-N-(6-((4-(2-hydroxypropan-2-yl)piperidin1-yl)methyl)-1-((1S,4S)-4-(isopropylcarbamoyl)cyclohexyl)-1Hbenzo[d]imidazol-2(3H)-ylidene)benzamide], a new, potent, selective anaplastic lymphoma kinase (ALK) inhibitor with potential application for the treatment of cancer, was selected as candidate to advance into efficacy studies in mice. However, the compound underwent mouse...

The Hydrological Dispersion Module (HDM) of the RODOS (real-time on-line decision support) system for nuclear emergency management in Europe has been is developed at IMMSP, Kiev, Ukraine; NRG, The Netherlands; FZK, Karlsruhe, Germany; SPA “TYPHOON”, Obninsk, Russia; IPEP, Minsk, Belorussia, and NCSR “Demokritos”, Athens, Greece. Initial testing and customisation work was performed by NPPRI, Slo...

many other oral lesions and rarely is tuberculosis at the top of the list of differential diagnoses.2 In the older texts, when tuberculosis was more common, the ulcers were described as being painless and found mainly on the tongue and occasionally on the gingivae. Patients seem to be taking longer to seek advice for such lesions and the pain is probably related to further infection of the ulce...

It is shown that there are three vacuum and one electrovacuum solutions of diagonal plane waves with M = 0 and constant Maxwell scalars. Namely, these are the single wave, Stoyanov, Babala and Bell-Szekeres solutions. A comparison is made with the planar solutions of Taub.

b ac k gr o und: w o lbachia pipientis is maternally inherited endoparasitic bacterium belonging to the α-proteobacteria, infecting 20–75% of all insect species including sand flies. the wolbachia surface protein ( wsp ) was employed as an appropriate marker for strain typing. the objective of our research was to find the possibility of detection of w. p ipientis in phlebotomus perfiliewi trans...

Simultaneous Characterizations of Reflex and nonreflex, dynamic and static 1 changes in spastic hemiparesis 2 3 Li-Qun Zhang, Sun G. Chung, Yupeng Ren, 4 Lin Liu, Elliot J. Roth and W. Zev Rymer 5 6 Department of Physical Medicine and Rehabilitation 7 Department of Orthopaedic Surgery 8 Department of Biomedical Engineering 9 Department of Physiology 10 Northwestern University 11 Rehabilitation ...

In this paper, we study $L^p$-conjecture on locally compact hypergroups and by some technical proofs we give some sufficient and necessary conditions  for a weighted Lebesgue space  $L^p(K,w)$ to be a convolution Banach algebra, where $1<p<infty$, $K$ is a locally compact hypergroup and $w$ is a weight function on $K$.  Among the other things, we also show that if $K$ is a locally compact hyper...

Direct use of poultry manure (PM) as an organic fertilizer in agriculture may cause environmental concerns; therefore, application of its biochar might be an effective solution. A greenhouse experiment was conducted to investigate the influence of PM and its biochar (PMB) (control, 1% and 2% PM (w/w), 1% and 2% (W/W) PMB) on the growth and micronutrients concentration of corn under salinity str...

Two new heterogenized epoxidation nanocatalysts based on molybdenum and tungsten compounds were prepared withcovalent grafting of MCM-41 with 3-aminoropropyl trimethoxysilane and subsequent reaction with diphenylphosphinobenzaldehyde and complexation with M (Mo, W)O2(acac)2. X-ray diffraction and nitrogen sorption analyses revealed the preservation of the textural properti...

In this paper we investigate Werner Stark’s sociology of knowledge approach in the history economic thought. This explores: 1) strengths and weaknesses to historiography, 2) how can frame an understanding mercantilist writings, 3) development a link between pluralist economics approach. The reason for developing is extend encompass theorizing and, at same time, clarify context theory . John May...