نتایج جستجو برای: 231 demonstrated clear polymorphism
تعداد نتایج: 779823 فیلتر نتایج به سال:
1 The Florey Institute of Neuroscience and Mental Health, Parkville, Victoria, Australia 2 CogState Ltd., Melbourne, Victoria, Australia 3 Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USA 4 Academic Unit for Psychiatry of Old Age, St. Vincent’s Health, Department of Psychiatry, The University of Melbourne, Kew, Victoria, Australia 5 National Ageing Research Insti...
We have performed a genome-wide analysis of common genetic variation controlling differential expression of transcript isoforms in the CEU HapMap population using a comprehensive exon tiling microarray covering 17,897 genes. We detected 324 genes with significant associations between flanking SNPs and transcript levels. Of these, 39% reflected changes in whole gene expression and 55% reflected ...
for social rather than medical reasons—i.e., in terms of their age, education, ethnicity, marital status, inner-city and rural residence and ability to pay for services.3 This patient profile suggests that midwives are primarily being used to fill health care gaps among the economically disadvantaged. New Medicaid reimbursement regulations could be partially responsible for this relationship,4 ...
Notch signalling is involved in a multitude of developmental decisions and its aberrant activation is linked to many diseases, including cancers. One example is the neural stem cell tumours that arise from constitutive Notch activity in Drosophila neuroblasts. To investigate how hyperactivation of Notch in larval neuroblasts leads to tumours, we combined results from profiling the upregulated m...
Ovarian clear cell carcinoma (CCC) is generally associated with chemoresistance and poor clinical outcome, even with early diagnosis; whereas high-grade serous carcinomas (SCs) and endometrioid carcinomas (ECs) are commonly chemosensitive at advanced stages. Although an integrated genomic analysis of SC has been performed, conclusive views on copy number and expression profiles for CCC are stil...
One of the parasite diseases associated with the consumption of raw fish that occurs with some frequency is the anisakiasis, a human disease caused by the accidental ingestion of larval nematodes of the genus Anisakis, family Anisakidae. At the National Reference Centre for Anisakiasis (C.Re.N.A.) from October 2012 to February 2013, a number of 231 bony fish (Trichiuridae, Engraulidae, Scombrid...
The prion diseases seem to be caused by a conformational change of the prion protein (PrP) from the benign cellular form PrPC to the infectious scrapie form PrPSc; thus, detailed information about PrP structure may provide essential insights into the mechanism by which these diseases develop. In this study, the secondary structure of the recombinant Syrian hamster PrP of residues 29-231 [PrP(29...
Abstract An mRNA transcript that codes for a Disintegrin and Metalloprotease from venom gland of the viper Bothrops ammodytoides was isolated. Vector pCR®2.1-TOPO used to clone then subcloned in pET-28a vector express protein E. coli strain BL21. The recombinant disintegrin, HisrDisintegrin, comprises 38 residues at N-terminal 75 Disintegrin, including 14 cysteines or 7 disulfide bonds. HisrDis...
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