نتایج جستجو برای: 23 793
تعداد نتایج: 188577 فیلتر نتایج به سال:
IL-23 plays a critical role in EAE induced by the active immunization of C57BL/6 mice with an immunodominant epitope of myelin oligodendrocyte glycoprotein (MOG(35-55)). It was initially assumed that the pathogenic effects of IL-23 were directly related to the generation, expansion and/or stabilization of autoreactive CD4(+) Th17 cells. However, a number of recent studies have uncovered discrep...
The interleukin-23 (IL-23) pathway plays a critical role in the pathogenesis of multiple chronic inflammatory disorders, however, inter-individual variability in IL-23-induced signal transduction in circulating human lymphocytes has not been well-defined. In this study, we observed marked, reproducible inter-individual differences in IL-23 responsiveness (measured by STAT3 phosphorylation) in p...
Mutations in the IL23R gene are linked to inflammatory bowel disease susceptibility. Experimental models have shown that interleukin-23 (IL-23) orchestrates innate and T cell-dependent colitis; however, the cell populations it acts on to induce intestinal immune pathology are unknown. Here, using Il23r(-/-) T cells, we demonstrated that T cell reactivity to IL-23 was critical for development of...
IL-23 plays an important role in autoimmune tissue inflammation and induces the generation of not fully characterized effector cells that mediate protection against pathogens. In this paper, we established the essential role of IL-23R in the host response against intracellular pathogens. IL-23 was critical for the expansion or maintenance of gammadelta and double negative (DN) alphabeta T cells...
OBJECTIVE IL-23 is a pro-inflammatory cytokine proposed to be central to the development of autoimmune disease. We investigated whether IL-23, together with the downstream mediator IL-17A, was present and functional in RA in humans. METHODS RA synovial cells were cultured in the presence or absence of antibodies directed against IL-23p19 or -23R and -17. IL-23, -12, -17, and their receptors, ...
793-1 Local, Low Pressure Heparin Delivery Following Angioplasty in Man: The Solution to Restenosls?
با توجه به این که ایران در منطقه خشک و نیمه خشک قرار دارد، در بسیاری از مناطق آن محدودیت منابع آّب شیرین باعث شده تا کشاورزان به منظور تولید محصولات زراعی از آب های با کیفیت پایین و شور استفاده کنند. به همین سبب در تمام دنیا مدیریت تولید محصولات کشاورزی به خصوص سبزی ها تحت شرایط شور بسیار مورد توجه قرار گرفته است. سبزی ها و صیفی جات به عنوان مهم ترین منابع تأمین کننده مواد غذایی انسان ها، از اهم...
ﻫﺪف از اﻳﻦ ﭘﮋوﻫﺶ ﻣﻘﺎﻳﺴﻪ ﺗﺎﺛﻴﺮ ﺗﻤﺮﻳﻨﺎت ﺳﻨﺘﻲ و ﺗﻤﺮﻳﻨﺎت ﺑﺎ ﺣﻤﺎﻳﺖ وزن (bwst) ﺑﺮ ﺗﺮاﻛﻢ اﺳﺘﺨﻮان و ﺑﻴﻮﻣﺎرﻛﺮﻫﺎی ﺳﺮﻣﻲ ﻣﺘﺎﺑﻮﻟﻴﺴﻢ اﺳﺘﺨﻮان در اﻓﺮاد ﭘﺎراﭘﻠﮋی ﻣﻲ ﺑﺎﺷﺪ. ﺗﻌﺪاد 17 ﻧﻔﺮ ﺿﺎﻳﻌﻪ ﻧﺨﺎﻋﻲ ﭘﺎراﭘﻠﮋی (ﻃﺒﻘﻪ ﺑﻨﺪی asia b,c)، ﺳﻦ 32/53±1/793 ﺳﺎل، ﻗﺪ 175/71±1/658 ﺳﺎﻧﺘﻲﻣﺘﺮ، وزن 71/59±2/442 ﻛﻴﻠﻮﮔﺮم و ﺷﺎﺧﺺ ﺗﻮده ﺑﺪﻧﻲ (bmi) 23/18±0/828 ﻛﻴﻠﻮﮔﺮم ﺑﺮ ﻣﺘﺮ ﻣﺮﺑﻊ ﺑﻄﻮر دﺳﺘﺮس و داوﻃﻠﺒﺎﻧﻪ ﺑﻪ ﻋﻨﻮان آزﻣﻮدﻧﻲ اﻧﺘﺨﺎب ﺷﺪﻧﺪ. اﻳﻦ...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید