Recent radio VLBI observations of the complex gravitationally lensed system PKS1830-211 have thrown up some questions with regard to the processes occuring at the heart of the blazar source at a redshift of 2.51, which is viewed almost straight down the jet axis. This work links, by a model of a helical jet tracked by ballistically ejected plasmons from a precessing nozzle, observations on the ...

The possibility of using spatial solitary waves for implementation of optical logic and switching has led to a number of experimental and theoretical investigations of the interactions between spatial solitons.1–8 An extensive discussion of geometrical and material alternatives for implementing optical soliton switches was given in Ref. 9. Initial experimental work in this area centered on Kerr...

UNLABELLED Two characteristics of alpha-particles that enhance their potential for targeted radiotherapy are their high energy and approximately cellular range. Unfortunately, these properties also can have negative consequences, confounding the production of clinically relevant levels of radiopharmaceutical because of radiolytic effects. The purpose of this study was to evaluate the effect of ...

The leucine 211 --> phenylalanine (L211F) and leucine 211 --> tyrosine (L211Y) mutant forms of cytochrome P450 3A4 have been generated by site-directed mutagenesis and expressed functionally in Escherichia coli. Substrate binding affinities (S50 values) for testosterone and 7-benzyloxy-4-trifluoromethylcoumarin (BFC) were similar for the mutants and wild-type CYP3A4 (49 and 21 microM for L211F,...

We present the design of ALMA Band 5 sideband separation mixer based on Niobium superconducting SIS junctions and first experimental results for the double side band mixer. In this mixer the LO injection circuitry is integrated on the mixer substrate using a microstrip line directional coupler with slot-line branches in the ground plane. The isolated port of the LO coupler is terminated by a wi...