BACKGROUND Oxygen therapy is an important therapeutic resource for patients with hypoxemia. When changing oxygen flow meters, we have observed that sometimes, even with the same oxygen flow setting as before, a different S(pO(2)) is obtained. OBJECTIVE To analyze the precision and accuracy of flow meters used in hospital settings. METHODS An experimental study was performed to test oxygen ...

We have examined the ligand regulation and G protein selectivity of the human cannabinoid CB(1) and CB(2) receptors by an in situ reconstitution technique directly measuring G protein activation. Membranes from Spodoptera frugiperda cells expressing CB(1) and CB(2) receptors were chaotrope extracted to denature endogenous GTP-binding proteins. The ability of the receptors to catalyze the GDP-GT...

BACKGROUND Circulating micro-RNAs have been proposed as a novel class of cardiovascular (CV) biomarkers, but whether they meet analytical requirements and provide additional information to establish risk indices have not been established. miR-210 levels are increased in subjects with low VO2 max, which is a recognized risk factor in patients with aortic stenosis (AS), and we hypothesized that c...

Preeclampsia is a pregnancy-specific syndrome manifested by the onset of hypertension and proteinuria after the 20th week of gestation. Abnormal placenta development has been generally accepted as the initial cause of the disorder. Recently, microRNA-210 (miR-210) has been found to be upregulated in preeclamptic placentas compared with normal placentas, indicating a possible association of this...

Google Earth now hosts high-resolution imagery that spans twenty percent of the Earth's landmass and more than a third of the human population. This contemporary highresolution archive represents a significant, rapidly expanding, cost-free and largely unexploited resource for scientific inquiry. To increase the scientific utility of this archive, we address horizontal positional accuracy (geore...

The problem of preservation and transformation the existing dendropark natural forest in conditions urban development middle zone city is considered. park located scientific campus Siberian Branch Academy Sciences Irkutsk. territory has properties a landscape park. At same time, it actively used as walking area for sports activities. There are risks using land housing construction because surro...

Several transmission and distribution companies in Western Europe operate test facilities for testing industrial meters like larger diaphragm gas meters, rotary gas meters and turbine gas meters. Alternatively, they lease mobile provers. Those installations are not suitable to perform the initial calibration (and try to save money on the calibration costs), but are suitable to perform all kind ...

Having been ignored for the most part, analytical accuracy of blood glucose (BG) meters is now the subject of a considerable series of studies (manuscripts). While the results of these studies show considerable differences between meters, they also show that many meters have good analytical quality, i.e., in the hands of highly trained technicians and optimally controlled environmental conditio...

In the present study, we studied the mechanism of mitochondrial ATP-sensitive potassium (mitoKATP) channels regulating hypoxia-inducible factor (HIF)-1α/microRNA (miR)-210/mitochondrial iron-sulfur protein integrin (ISCU) signaling axis and forming a positive feedback loop in chronic hypoxia-induced pulmonary arterial hypertension (PAH) by using in vivo animal model. Two hundred healthy adult S...