This study evaluated a novel method for modulation of neuronal excitability using non-invasive delivery of millimeter waves. Millimeter waves at 60 GHz and incident power density of 100-600 μW/cm were applied to three intact segmental ganglia of the adult leach, and intracellular neuronal activity was recorded from the Retzius neurons using intracellular glass electrode. Transient dosedependent...

It has been shown recently that death of cells simultaneously exposed to ionizing radiation and static electric fields is substantially higher than in cells only irradiated, suggesting that a static electric field interferes with cell repair mechanisms. In the present work, T47D breast cancer cells were firstly irradiated with 1 and 2 Gy of gamma radiation, and then exposed to a SEF of 1250 V/c...

Purpose: Clinical trials to develop vitamin D3-based therapies for advanced prostate cancer were hindered by the risk of hypercalcemia and the limited antitumor benefit. We aimed to define factors predictive of the tumor growth response to vitamin D3 in patients with prostate cancer and specifically examine the role of its major catabolic enzyme, CYP24A1 in prostate tumorigenesis. Experimental ...

Low temperature heating systems for single-family houses, based on heat pumps are becoming progressively more preferable in the global market. The possibility of such systems to optimise the energy utilisation and to achieve a high annual energy efficiency make them more promising for future low energy houses. In this study we model and analyse the performance of a low temperature heating syste...

This study investigated the hepatoprotective and antioxidant response to intraperitoneal, intravenous, subcutaneous and oral treatment with quercetin in adult male Wistar rat. The animals were divided randomly into the four groups according to the routes of administration. Quercetin was allowed to react with selected hepatic isoenzymes (aspartate amino transferase, alanine amino transferase) vi...

Comparative genetic mapping studies reveal similarities and differences in gene content and gene order between genera belonging to different taxa. A pressing need in legume genomics is to integrate knowledge gained from the study of model legume genomes with the biological and agronomic questions of importance in the crop species. It is important to know whether similar features are prevalent i...

Appearance of bone metastases is the most common complication of oncological diseases. They are usually incurable, produce severe pain, decreasing the expectancy and quality of life of patients. The use of radiopharmaceuticals for bone metastatic pain palliation have shown significant advantages. Bisphosphonates are the main compounds employed for that purpose; nevertheless, their synthesis is ...

We report the identification of a hitherto unknown nucleotide that is present in micromolar concentrations in the erythrocytes of healthy subjects and accumulates at levels comparable with the ATP concentration in erythrocytes of patients with chronic renal failure. The unknown nucleotide was isolated and identified by liquid chromatography with UV and tandem mass detection, H nuclear magnetic ...

Protein kinases carry out important functions in cells both by phosphorylating substrates and by means of regulated noncatalytic activities. Such non-catalytic functions have been ascribed to many kinases, including some members of the Ste20 family. The Drosophila Ste20 kinase Slik phosphorylates and activates Moesin in developing epithelial tissues to promote epithelial tissue integrity. It al...