PURPOSE To determine the expression of luteinizing hormone releasing hormone (LHRH) receptors in specimens and cell lines of human renal cell carcinoma (RCC) and to evaluate the antitumor efficacy of targeted therapy with a cytotoxic analogue of LHRH, AN-207, in vivo. AN-207, consisting of [D-Lys(6)] LHRH linked to a cytotoxic radical, 2-pyrrolinodoxorubicin (AN-201), binds with high affinity t...

BACKGROUND Two common mutations of the haemochromatosis associated gene (HFE) (cys282tyr (C282Y) and his63asp (H63D)) have been implicated in haemochromatosis and as modulators in cardiovascular disease. OBJECTIVE To investigate the role of these mutations in the pathogenesis of idiopathic dilated cardiomyopathy. DESIGN AND SETTING Case-control and prospective cohort study of patients atten...

BACKGROUND This study aimed to show the localization of estrogen / progesterone receptors, human epidermal growth factor receptor 2 (Her-2) and protein 53 (p53) by immunohistochemistry in a series of consecutive breast cancer patients. MATERIALS AND METHODS The study covered invasive breast cancers from 299 patients presenting at the Oncogenetic Clinic and Pathology Centers of Ahwaz Jondishap...

Lead (Pb) concentrations and isotopic compositions from soils, dusts and aerosols from public land and residential lots adjacent to the copper and Pb mine and smelter at Mount Isa, Australia, were examined to understand the sources and risks of environmental Pb exposure. Urban soil samples contain elevated Pb concentrations (mean 1560 mg/kg), of which 45-85% of the Pb is bioaccessible. The Pb i...

a, 71 a/an, 58, 112 Academie Franҫaise, 96 acoustic phonetic, 24, 62, 184, 192 A-curve, 24, 28, 31, 32, 33, 34, 58, 62, 66, 74, 84, 93, 96, 98, 100, 101, 112, 113, 119, 125, 134, 147, 153, 159, 166, 167, 168, 171, 179, 182, 184, 189 aesthetic, 131, 160 aesthetics, 131, 132, 150, 154, 160 Africa, 45 Agarwal, 141 all grammars leak, 93 Allen, 48 American Dialect Society, 207, 208 American Speech, ...

We have identified a family of abundant peripheral plasma membrane glycoproteins that is unique to flowering plants. They are identified by a monoclonal antibody, MAC 207, that recognizes an epitope containing L-arabinose and D-glucuronic acid. Immunofluorescence and immunogold labeling studies locate the MAC 207 epitope to the outer surface of the plasma membrane both in protoplasts and in int...

Background: Acute malnutrition (severe and moderate) is a major public health problem in India especially Rajasthan. National family surveys now provide prevalence of SAM children till district level but there’s an undenying need for data at even more granular, like block level, to assess the field reality depth. The present study tries demystify same by studying collected from community-based ...

This study explores the social impact of ADHD, with and without opposition-defiant behaviour (ADHD+ODD (n= 22) and ADHD-only (n= 18)), in 9- to 12- year old girls compared to girls without ADHD (n= 40). Girls played a computer game involving simulated players, and mothers and teachers completed rating scales. In general, mothers and teachers saw girls with ADHD+ODD as more overtly and relationa...

Findings regarding phenotypic differences between boys and girls with ASD are mixed. We compared autism and internalizing symptoms in a sample of 8-18 year-old girls (n = 20) and boys (n = 20) with ASD and typically developing (TYP) girls (n = 19) and boys (n = 17). Girls with ASD were more impaired than TYP girls but did not differ from boys with ASD in autism symptoms. In adolescence, girls w...

The Rockefeller University Press $30.00 J. Exp. Med. Vol. 207 No. 1