Serological analysis of recombinant cDNA expression libraries (SEREX) has led to the identification of many of the antigens recognized by the immune system of cancer patients, which are collectively referred to as the cancer immunome. We used SEREX to screen a testicular cDNA expression library with sera obtained from non-small cell lung cancer patients and isolated cDNA clones for 82 antigens....

We studied telomere length in 32 CML patients who discontinued imatinib after achieving complete molecular remission and 32 age-sex-matched controls. The relative telomere length (RTL) was determined by q-PCR as the telomere to single copy gene (36B4) ratio normalized to a reference sample (K-562 DNA). Age-corrected RTL (acRTL) was also obtained. The 36-month probability of treatment-free remis...

Reese, E. T. (1956). Appl. Microbiol. 4, 39. Reese, E. T., Segal, L. & Tripp, V. W. (1957). Text. Res. J. 27, 626. Reese, E. T., Siu, R. G. H. & Levinson, H. S. (1950). J. Bad. 59, 485. Searle, G. 0. (1929). J. Text. Inst. 20, T162. Selby, K. (1961). Biochem. J. 79, 562. Selby, K. (1963). In Advance8 in Enzymic Hydroly8is of CellUlo8e and Related Materials, p. 33. Ed. by Reese, E. T. Oxford: Pe...

We compared prediction of in vivo dry matter (DMD) and neutral detergent fiber (aNDFD) digestibility by the following techniques: (1) Tilley and Terry two-stage in vitro (conventional in vitro or IVDMD), (2) DaisyII in vitro (DaisyII), and (3) filter bag in situ preceded by 48 h acid–pepsin treatment. In addition, we also evaluated the effects due to sample size (0.25 g versus 0.50 g) and Wiley...

BACKGROUND Access to pediatric antiretroviral formulations is increasing in resource-limited countries, however adult FDCs are still commonly used by antiretroviral therapy (ART) programs. OBJECTIVE To describe long-term effectiveness of using adult FDC of d4T+3TC+NVP (Triomune) in children for HIV treatment. METHODS Clinical, immunologic, and virologic outcomes of HIV-infected ART-naïve ch...

NY-ESO-1 is one of the most immunogenic cancer antigens known to date, eliciting spontaneous immune responses in approximately 50% of patients with NY-ESO-1+ cancers. Spontaneous CD4+ and CD8+ T cell responses were found in patients with detectable NY-ESO-1 serum antibody, indicating an integrated type of immune response induced by NY-ESO-1+ malignancies. A close association between spontaneous...

Merkel cell carcinoma (MCC) is an aggressive skin cancer that recurs in 40% of cases. Effective surveillance crucial for disease management. This prospective, multicenter study assessed the utility circulating tumor DNA (ctDNA) to assess burden and detect early recurrence MCC patients. Whole-exome sequencing was performed on tissue identify tumor-specific, single nucleotide variants each patien...

Chemotherapy is a common treatment for leukemia. Ruthenium complexes have shown potential utility in chemotherapy and photodynamic therapy. The identification of new chemotherapeutics agents is critical for further progress in the treatment of leukemia. Ruthenium complexes generally have lower toxicities compared to cisplatin attributed to their specific accumulation in cancer tissues. Based on...

The effective microorganism (EM-X) fermentation extract is derived from rice bran and seaweed extract. It has been shown to possess anti-oxidation activity both in vitro and in vivo. To our knowledge, the possible in vitro anti-cancer potential of EM-X has not been demonstrated. Here we showed that the double concentrate of EM-X (EM-X2) at concentrations of 20-30% by volume, had growth inhibito...

The return performance and factor sensitivities of Canadian equity real estate investment trusts (E-REITs) are examined. Today, typical and average Canadian E-REIT IPOs are correctly priced based on first-day and subsequent short-run returns. The overpricing evident earlier in the 1993-96 period for typical and average E-REIT IPOs has corrected. E-REITs are equity investments with about one-hal...