This chapter identifies and discusses issues relevant to the psychosocial evaluation of perinatal substance abusers. The conclusions are based on 5 years of experience with 133 women treated at Virginia Commonwealth University’s National Institute on Drug Abuse (NIDA)-funded Treatment Research Unit, the Center for Perinatal Addiction (CPA). The chapter begins with a brief overview of measuremen...

One in 20 prescriptions written by GPs in England contains an error, and one in 550 contains a serious error, a large study has found. The prevalence and causes of prescribing errors in general practice study, commissioned by the General Medical Council, shows that it is not doctors’ knowledge about drugs that is responsible for most errors but human factors and process issues. Errors chiefly o...

Neuroactive steroids are synthesized de novo in brain, yet their physiological significance remains elusive. We provide biochemical, electrophysiological, and behavioral evidence that several specific actions of alcohol (ethanol) are mediated by the neurosteroid 3a-hydroxy-5a-pregnan-20-one (3a,5a-THP; allopregnanolone). Systemic alcohol administration elevates 3a,5a-THP levels in the cerebral ...

The shortage of cadaveric donor organs remains the critical factor limiting the use of organ transplantation. In this environment of organ shortage, living donor transplantation has emerged as a reasonable therapeutic alternative. Simultaneous kidney-liver transplantation from the same donor has been described. We report a case of right liver lobe transplant from a living donor who had donated ...

introduction: infants born with congenital anomalies demand individualized nutritional evaluations and recommendations. the anatomical changes of neonatal surgical diseases create specific physiological constraints.patients with different congenital anomalies have different nutritional support needs. it is essential to know the exact physiology of these anomalies in order to be able to manage a...

We have created one-, two-, and three-dimensional quantum gases and study the superfluid to Mott insulator transition. Measurements of the transition using Bragg spectroscopy show that the excitation spectra of the low-dimensional superfluids differ significantly from the three-dimensional case. A low dimensional gas can be created in a trap when the confining potential restricts the motion of ...

Direct NMR hyperpolarization of naturally abundant (15)N sites in metronidazole is demonstrated using SABRE-SHEATH (Signal Amplification by Reversible Exchange in SHield Enables Alignment Transfer to Heteronuclei). In only a few tens of seconds, nuclear spin polarization P(15)N of up to ∼24% is achieved using parahydrogen with 80% para fraction corresponding to P(15)N ≈ 32% if ∼100% parahydroge...

The most general nonuniform reaction-diffusion models on a one-dimensional lattice with boundaries, for which the time evolution equations of correlation functions are closed, are considered. A transfer matrix method is used to find the static solution. It is seen that this transfer matrix can be obtained in a closed form, if the reaction rates satisfy certain conditions. We call such models su...