Di- or tetracarboxylic acid ligands were used to isolate molecular coordination complexes containing the association of several mononuclear {Nb 1 } moiety and dinuclear 2 O} niobium( v ) polyoxo clusters.

This study was conducted to investigate the effect of the reduced function allele CYP2D6*10, which can be the cause of an intermediate metabolizer (IM), on tolterodine pharmacokinetics. Tolterodine is mainly metabolized to an active 5-hydroxymethyl metabolite (5-HM) by CYP2D6, and 5-HM is also metabolized by CYP2D6. Asian and white healthy volunteers (n = 108) received once daily multiple doses...

In this study, the optical properties and excited-state dynamics of unique self-assembled donor-acceptor (DA) merocyanine dye stacks from dimer up to octamer, prepared via dipole-dipole interactions, are reported in terms coherent exciton formation an excimer-like state. Our findings based on steady-state absorption/emission, time-resolved fluorescence, transient absorption (anisotropy) measure...

(2S,3R)-3-Amino-2-hydroxyoctanoic acid was synthesized by Curtius rearrangement of an azide derivative of (S)-malic acid. Total syntheses of valinoctin A and its analogues were achieved by a coupling of (2S, 3R)-3-amino-2-hydroxyoctanoic acid moiety with L-valine or several other amino acids moieties. 2S configuration of 3-amino-2-hydroxyoctanoic acid moiety was found to be important for the in...

Plants are a rich source of secondary metabolites or chemical constituents with interesting biological activities. Therefore, thorough validation the herbal agents has emerged as new branch science emphasizing and prioritizing standardization natural drugs products because several these phytochemicals have complementary overlapping mechanism action. Mass spectrometry coupled chromatographic sep...

Functionalized vinyl pinacol boronates suitable for Suzuki cross-coupling reactions are synthesized using ruthenium-catalyzed olefin cross-metathesis of 1-propenyl pinacol boronate and various alkenes, including functionalized and 1,1-disubstituted alkenes. The resultant boronate cross products are stereoselectively transformed into predominantly Z-vinyl bromides and E-vinyl iodides. The vinyl ...

The levels of DNA, RNA and Protein were estimated in cerebral hemisphere, cerebellum and brain stem of male albino rats with Nuvacron (0, 0, dimethyl-0-1 methyl 3-methylamino-3-oxe-1-propenyl phosphate) 4 mg/kg body weight intraperitoneally (i.p.) daily for 10 days. The daily i.p. dose of Nuvacron depleted the level of DNA and protein in all brain regions. Increased level of RNA was observed in...

Onions contain high antioxidants compounds that fight inflammation against many diseases. The purpose was to investigate some selected bioactive activities of onion varieties (Yellow, Red, Green, Leek, and Baby). Antioxidant assays anti-inflammatory such as NO production with the addition components were determined analyzed by using a spectrophotometer. Gas chromatography mass spectrometry (GC–...